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MK-2206

(CAS No:1032350-13-2)

MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.

CAS No:1032350-13-2

Molecular Weight(MW):480.39

Purity:99.00%

Specification:500MG;1G;5G;10G;50G;100G

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QC Documents

COA	MSDS	HPLC	NMR

ChemicalInfomation

CAS No:	1032350-13-2
Molecular formula(MF)	C₂₅H₂₁N₅O^.₂HCl
Molecular Weight(MW):	480.39
Alias

Solubility

In vitro	DMSO	14 mg/mL (29.14 mM)
	Water	<1 mg/mL
	Ethanol	<1 mg/mL
In vivo	15% Captisol	17 mg/mL

Biological Activity

Description

MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.

Features

The first allosteric small molecule inhibitor of Akt to enter clinical development.

Targets

Akt1 ^[1] (Cell-free assay)	Akt2 ^[1] (Cell-free assay)	Akt3 ^[1] (Cell-free assay)
8 nM	12 nM	65 nM

In vitro

MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. ^[1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. ^[2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
NCI-H292	Cytotoxic Assay	3 Î¼M	72 h	DMSO	Inhibition of cell proliferation	20571069
A431	Kinase Assay	5 Î¼M	5 h	DMSO	Suppresses the signaling of Akt and Erk	20571069
HepG2	Cytotoxic Assay	10 Î¼M	24 h	DMSO	Sensitizes resistant cells to the cytotoxic effect of sorafenib	21205925
Sk-Hep1	Cytotoxic Assay	10 Î¼M	24 h	DMSO	Sensitizes resistant cells to the cytotoxic effect of sorafenib	21205925
OCUT1 cells harbored PIK3CA (H1047R+/+)	Growth Inhibition Assay	3 Î¼M	5 d	DMSO	IC50=0.14 Î¼M	21289267
K1 cells harbored PIK3CA (E542K+/+)	Growth Inhibition Assay	3 Î¼M	5 d	DMSO	IC50=0.52 Î¼M	21289267
FTC133 cells harbored PTEN (allele deletion and R130+)	Growth Inhibition Assay	3 Î¼M	5 d	DMSO	IC50=0.18 Î¼M	21289267
C643 cells harbored HRAS (G13R+/−)	Growth Inhibition Assay	3 Î¼M	5 d	DMSO	IC50=0.27 Î¼M	21289267
Hth7 cells harbored NRAS (Q61R+/−)	Growth Inhibition Assay	3 Î¼M	5 d	DMSO	IC50=4.5 Î¼M	21289267
TPC1 cells harbored RET/PTC1 rearrangement	Growth Inhibition Assay	3 Î¼M	5 d	DMSO	IC50=0.59 Î¼M	21289267
Hth74	Growth Inhibition Assay	3 Î¼M	5 d	DMSO	IC50=2.19 Î¼M	21289267
KAT18	Growth Inhibition Assay	3 Î¼M	5 d	DMSO	IC50=4.62 Î¼M	21289267
SW1736	Growth Inhibition Assay	100 Î¼M	5 d	DMSO	IC50=47.56 Î¼M	21289267
WRO	Growth Inhibition Assay	1000 Î¼M	5 d	DMSO	IC50>1000 Î¼M	21289267
TAD2	Growth Inhibition Assay	1000 Î¼M	5 d	DMSO	IC50>1000 Î¼M	21289267
LN229	Apoptosis Assay	0.5 Î¼M	60 h	DMSO	Augments apoptogenic effects of gefitinib	22057914
T98G	Apoptosis Assay	0.5 Î¼M	60 h	DMSO	Augments apoptogenic effects of gefitinib	22057914
HC11	Function Assay	10 Î¼M	24 h	DMSO	Inhibits Î²-casein and ADRP synthesis	22426621
MOLT-4	Cytotoxic Assay	10 Î¼M	48 h	DMSO	IC50=1.7âÎ¼M	22614243
CEM-R	Cytotoxic Assay	10 Î¼M	48 h	DMSO	IC50=3.3âÎ¼M	22614243
CEM-S	Cytotoxic Assay	10 Î¼M	48 h	DMSO	IC50=5.1âÎ¼M	22614243
MOLT-4	Function Assay	10 Î¼M	24 h	DMSO	Blocks cells in the G0/G1 phase of the cell cycle	22614243
MOLT-4	Function Assay	4âÎ¼M	4 h	DMSO	Increases the amount of cleaved LC3A/B, a well-established autophagy marker	22614243
CEM-R	Function Assay	4âÎ¼M	4 h	DMSO	Increases the amount of cleaved LC4A/B, a well-established autophagy marker	22614243
CEM-S	Function Assay	4âÎ¼M	4 h	DMSO	Increases the amount of cleaved LC5A/B, a well-established autophagy marker	22614243
HepG2 cell	Kinase Assay	20 Î¼M	24 h	DMSO	Downregulates the phosphorylation of AKT	23797319
HepG2 cell	Growth Inhibition Assay	30 Î¼M	24 h	DMSO	Inhibits cell growth	23797319
HepG2 cell	Apoptosis Assay	20 Î¼M	24 h	DMSO	Induces cell apoptosis	23797319
GEO	Growth Inhibition Assay	500 nM	72 h	DMSO	Inhibits cell growth	24581231
CNE-1	Growth Inhibition Assay	10 Î¼M	96 h	DMSO	IC50=2.96 Î¼M	25336925
CNE-2	Growth Inhibition Assay	10 Î¼M	96 h	DMSO	IC50=4.53 Î¼M	25336925
HONE-1	Growth Inhibition Assay	10 Î¼M	96 h	DMSO	IC50=3.37 Î¼M	25336925
SUNE-1	Growth Inhibition Assay	10 Î¼M	96 h	DMSO	IC50=0.52 Î¼M	25336925
CNE-2	Function Assay	10 Î¼M	48 h	DMSO	Induces cell cycle arrest at G1	25336925
HONE-1	Function Assay	10 Î¼M	48 h	DMSO	Induces cell cycle arrest at G1	25336925
NEC8	Growth Inhibition Assay				IC50=0.09651 Î¼M	SANGER
P12-ICHIKAWA	Growth Inhibition Assay				IC50=0.1162 Î¼M	SANGER
MDA-MB-175-VII	Growth Inhibition Assay				IC50=0.13738 Î¼M	SANGER
AsPC-1	Growth Inhibition Assay				IC50=0.22122 Î¼M	SANGER
T47D	Growth Inhibition Assay				IC50=0.2825 Î¼M	SANGER
HH	Growth Inhibition Assay				IC50=0.30283 Î¼M	SANGER
MOLT-16	Growth Inhibition Assay				IC50=0.3032 Î¼M	SANGER
ES5	Growth Inhibition Assay				IC50=0.34455 Î¼M	SANGER
RS4-11	Growth Inhibition Assay				IC50=0.3461 Î¼M	SANGER
KARPAS-45	Growth Inhibition Assay				IC50=0.37321 Î¼M	SANGER
NCI-H720	Growth Inhibition Assay				IC50=0.37679 Î¼M	SANGER
H9	Growth Inhibition Assay				IC50=0.38883 Î¼M	SANGER
EFM-19	Growth Inhibition Assay				IC50=0.4401 Î¼M	SANGER
SBC-1	Growth Inhibition Assay				IC50=0.44035 Î¼M	SANGER
A4-Fuk	Growth Inhibition Assay				IC50=0.46868 Î¼M	SANGER
NCI-H1563	Growth Inhibition Assay				IC50=0.48189 Î¼M	SANGER
HCC1419	Growth Inhibition Assay				IC50=0.48892 Î¼M	SANGER
H-EMC-SS	Growth Inhibition Assay				IC50=0.49939 Î¼M	SANGER
BHT-101	Growth Inhibition Assay				IC50=0.52961 Î¼M	SANGER
IGROV-1	Growth Inhibition Assay				IC50=0.55249 Î¼M	SANGER
HGC-27	Growth Inhibition Assay				IC50=0.56783 Î¼M	SANGER
MDA-MB-361	Growth Inhibition Assay				IC50=0.57761 Î¼M	SANGER
KE-37	Growth Inhibition Assay				IC50=0.5826 Î¼M	SANGER
HCC70	Growth Inhibition Assay				IC50=0.59827 Î¼M	SANGER
LNCaP-Clone-FGC	Growth Inhibition Assay				IC50=0.61048 Î¼M	SANGER
HAL-01	Growth Inhibition Assay				IC50=0.6213 Î¼M	SANGER
HT	Growth Inhibition Assay				IC50=0.63239 Î¼M	SANGER
MDA-MB-415	Growth Inhibition Assay				IC50=0.63626 Î¼M	SANGER
NOS-1	Growth Inhibition Assay				IC50=0.63723 Î¼M	SANGER
DU-145	Growth Inhibition Assay				IC50=0.64745 Î¼M	SANGER
OCUB-M	Growth Inhibition Assay				IC50=0.70966 Î¼M	SANGER
VA-ES-BJ	Growth Inhibition Assay				IC50=0.73025 Î¼M	SANGER
J-RT3-T3-5	Growth Inhibition Assay				IC50=0.74403 Î¼M	SANGER
MOLT-4	Growth Inhibition Assay				IC50=0.80582 Î¼M	SANGER
NB7	Growth Inhibition Assay				IC50=0.82411 Î¼M	SANGER
L-363	Growth Inhibition Assay				IC50=0.83442 Î¼M	SANGER
NKM-1	Growth Inhibition Assay				IC50=0.86253 Î¼M	SANGER
HOP-92	Growth Inhibition Assay				IC50=0.87223 Î¼M	SANGER
OAW-42	Growth Inhibition Assay				IC50=0.8872 Î¼M	SANGER
HuO9	Growth Inhibition Assay				IC50=0.92751 Î¼M	SANGER
MFE-280	Growth Inhibition Assay				IC50=0.96465 Î¼M	SANGER
EM-2	Growth Inhibition Assay				IC50=0.97939 Î¼M	SANGER
NCI-H520	Growth Inhibition Assay				IC50=0.98592 Î¼M	SANGER
LB2241-RCC	Growth Inhibition Assay				IC50=0.99734 Î¼M	SANGER
SK-NEP-1	Growth Inhibition Assay				IC50=1.14485 Î¼M	SANGER
LXF-289	Growth Inhibition Assay				IC50=1.17156 Î¼M	SANGER
EPLC-272H	Growth Inhibition Assay				IC50=1.17256 Î¼M	SANGER
COLO-684	Growth Inhibition Assay				IC50=1.23725 Î¼M	SANGER
ES1	Growth Inhibition Assay				IC50=1.24065 Î¼M	SANGER
DOHH-2	Growth Inhibition Assay				IC50=1.28203 Î¼M	SANGER
CTB-1	Growth Inhibition Assay				IC50=1.2899 Î¼M	SANGER
G-401	Growth Inhibition Assay				IC50=1.29795 Î¼M	SANGER
LoVo	Growth Inhibition Assay				IC50=1.32534 Î¼M	SANGER
Ramos-2G6-4C10	Growth Inhibition Assay				IC50=1.33701 Î¼M	SANGER
MFM-223	Growth Inhibition Assay				IC50=1.34461 Î¼M	SANGER
PA-1	Growth Inhibition Assay				IC50=1.35265 Î¼M	SANGER
697	Growth Inhibition Assay				IC50=1.37616 Î¼M	SANGER
QIMR-WIL	Growth Inhibition Assay				IC50=1.49116 Î¼M	SANGER
HOS	Growth Inhibition Assay				IC50=1.49558 Î¼M	SANGER
DMS-273	Growth Inhibition Assay				IC50=1.51959 Î¼M	SANGER
ME-180	Growth Inhibition Assay				IC50=1.56891 Î¼M	SANGER
HCC2218	Growth Inhibition Assay				IC50=1.68225 Î¼M	SANGER
CAL-54	Growth Inhibition Assay				IC50=1.71242 Î¼M	SANGER
OMC-1	Growth Inhibition Assay				IC50=1.74677 Î¼M	SANGER
COR-L105	Growth Inhibition Assay				IC50=1.79737 Î¼M	SANGER
BV-173	Growth Inhibition Assay				IC50=1.81074 Î¼M	SANGER
RKO	Growth Inhibition Assay				IC50=1.87101 Î¼M	SANGER
SNU-387	Growth Inhibition Assay				IC50=1.88406 Î¼M	SANGER
SW1088	Growth Inhibition Assay				IC50=1.94606 Î¼M	SANGER
Hs-578-T	Growth Inhibition Assay				IC50=2.11433 Î¼M	SANGER
OC-314	Growth Inhibition Assay				IC50=2.15086 Î¼M	SANGER
RMG-I	Growth Inhibition Assay				IC50=2.16398 Î¼M	SANGER
NCI-H1395	Growth Inhibition Assay				IC50=2.18091 Î¼M	SANGER
GAMG	Growth Inhibition Assay				IC50=2.23845 Î¼M	SANGER
LB1047-RCC	Growth Inhibition Assay				IC50=2.24317 Î¼M	SANGER
MN-60	Growth Inhibition Assay				IC50=2.29923 Î¼M	SANGER
OAW-28	Growth Inhibition Assay				IC50=2.29951 Î¼M	SANGER
NCI-H2228	Growth Inhibition Assay				IC50=2.31552 Î¼M	SANGER
ABC-1	Growth Inhibition Assay				IC50=2.33253 Î¼M	SANGER
LS-513	Growth Inhibition Assay				IC50=2.33484 Î¼M	SANGER
KS-1	Growth Inhibition Assay				IC50=2.38191 Î¼M	SANGER
NB69	Growth Inhibition Assay				IC50=2.38983 Î¼M	SANGER
VM-CUB-1	Growth Inhibition Assay				IC50=2.39083 Î¼M	SANGER
D-423MG	Growth Inhibition Assay				IC50=2.41044 Î¼M	SANGER
EW-18	Growth Inhibition Assay				IC50=2.41939 Î¼M	SANGER
YH-13	Growth Inhibition Assay				IC50=2.46153 Î¼M	SANGER
T-24	Growth Inhibition Assay				IC50=2.47881 Î¼M	SANGER
ES8	Growth Inhibition Assay				IC50=2.49287 Î¼M	SANGER
ES3	Growth Inhibition Assay				IC50=2.49759 Î¼M	SANGER
RXF393	Growth Inhibition Assay				IC50=2.60487 Î¼M	SANGER
RPMI-8226	Growth Inhibition Assay				IC50=2.62953 Î¼M	SANGER
AGS	Growth Inhibition Assay				IC50=2.72137 Î¼M	SANGER
HCC1395	Growth Inhibition Assay				IC50=2.75187 Î¼M	SANGER
MV-4-11	Growth Inhibition Assay				IC50=2.75266 Î¼M	SANGER
A204	Growth Inhibition Assay				IC50=2.83872 Î¼M	SANGER
MCF7	Growth Inhibition Assay				IC50=2.86117 Î¼M	SANGER
SNU-423	Growth Inhibition Assay				IC50=2.89242 Î¼M	SANGER
NCI-H1048	Growth Inhibition Assay				IC50=2.96865 Î¼M	SANGER
GR-ST	Growth Inhibition Assay				IC50=3.04611 Î¼M	SANGER
EoL-1-	Growth Inhibition Assay				IC50=3.07058 Î¼M	SANGER
HuH-7	Growth Inhibition Assay				IC50=3.09464 Î¼M	SANGER
OS-RC-2	Growth Inhibition Assay				IC50=3.1119 Î¼M	SANGER
EW-3	Growth Inhibition Assay				IC50=3.19529 Î¼M	SANGER
NCI-H747	Growth Inhibition Assay				IC50=3.20694 Î¼M	SANGER
EW-16	Growth Inhibition Assay				IC50=3.21879 Î¼M	SANGER
DOK	Growth Inhibition Assay				IC50=3.22859 Î¼M	SANGER
HCC2157	Growth Inhibition Assay				IC50=3.38179 Î¼M	SANGER
OVCAR-3	Growth Inhibition Assay				IC50=3.40786 Î¼M	SANGER
NCI-H1623	Growth Inhibition Assay				IC50=3.41224 Î¼M	SANGER
H4	Growth Inhibition Assay				IC50=3.45626 Î¼M	SANGER
SW1710	Growth Inhibition Assay				IC50=3.46678 Î¼M	SANGER
RT-112	Growth Inhibition Assay				IC50=3.52388 Î¼M	SANGER
DMS-114	Growth Inhibition Assay				IC50=3.62278 Î¼M	SANGER
AN3-CA	Growth Inhibition Assay				IC50=3.62456 Î¼M	SANGER
KNS-62	Growth Inhibition Assay				IC50=3.63338 Î¼M	SANGER
SJRH30	Growth Inhibition Assay				IC50=3.69122 Î¼M	SANGER
G-402	Growth Inhibition Assay				IC50=3.70711 Î¼M	SANGER
MHH-PREB-1	Growth Inhibition Assay				IC50=3.72038 Î¼M	SANGER
P30-OHK	Growth Inhibition Assay				IC50=3.80976 Î¼M	SANGER
RVH-421	Growth Inhibition Assay				IC50=3.81788 Î¼M	SANGER
LU-134-A	Growth Inhibition Assay				IC50=3.88428 Î¼M	SANGER
ECC10	Growth Inhibition Assay				IC50=3.93622 Î¼M	SANGER
TGW	Growth Inhibition Assay				IC50=4.02305 Î¼M	SANGER
MLMA	Growth Inhibition Assay				IC50=4.02966 Î¼M	SANGER
SCC-25	Growth Inhibition Assay				IC50=4.06566 Î¼M	SANGER
TYK-nu	Growth Inhibition Assay				IC50=4.09534 Î¼M	SANGER
LAMA-84	Growth Inhibition Assay				IC50=4.14191 Î¼M	SANGER
Calu-3	Growth Inhibition Assay				IC50=4.24416 Î¼M	SANGER
NCI-H460	Growth Inhibition Assay				IC50=4.26443 Î¼M	SANGER
EGI-1	Growth Inhibition Assay				IC50=4.37778 Î¼M	SANGER
NCI-H292	Growth Inhibition Assay				IC50=4.38146 Î¼M	SANGER
HCE-T	Growth Inhibition Assay				IC50=4.41579 Î¼M	SANGER
EW-11	Growth Inhibition Assay				IC50=4.41838 Î¼M	SANGER
ATN-1	Growth Inhibition Assay				IC50=4.44304 Î¼M	SANGER
NB5	Growth Inhibition Assay				IC50=4.53697 Î¼M	SANGER
KLE	Growth Inhibition Assay				IC50=4.70198 Î¼M	SANGER
CAL-39	Growth Inhibition Assay				IC50=4.72146 Î¼M	SANGER
TI-73	Growth Inhibition Assay				IC50=4.80609 Î¼M	SANGER
HO-1-N-1	Growth Inhibition Assay				IC50=4.942 Î¼M	SANGER
786-0	Growth Inhibition Assay				IC50=4.94673 Î¼M	SANGER
SK-N-DZ	Growth Inhibition Assay				IC50=4.96142 Î¼M	SANGER
NCI-H446	Growth Inhibition Assay				IC50=5.20009 Î¼M	SANGER
ETK-1	Growth Inhibition Assay				IC50=5.21165 Î¼M	SANGER
BT-20	Growth Inhibition Assay				IC50=5.21353 Î¼M	SANGER
MEL-HO	Growth Inhibition Assay				IC50=5.37336 Î¼M	SANGER
CAL-27	Growth Inhibition Assay				IC50=5.46339 Î¼M	SANGER
SW872	Growth Inhibition Assay				IC50=5.59428 Î¼M	SANGER
RPMI-2650	Growth Inhibition Assay				IC50=5.66199 Î¼M	SANGER
PFSK-1	Growth Inhibition Assay				IC50=5.72732 Î¼M	SANGER
SF295	Growth Inhibition Assay				IC50=5.80633 Î¼M	SANGER
Becker	Growth Inhibition Assay				IC50=5.86472 Î¼M	SANGER
Saos-2	Growth Inhibition Assay				IC50=5.8653 Î¼M	SANGER
SK-OV-3	Growth Inhibition Assay				IC50=5.99816 Î¼M	SANGER
VMRC-RCZ	Growth Inhibition Assay				IC50=6.08773 Î¼M	SANGER
EW-22	Growth Inhibition Assay				IC50=6.19649 Î¼M	SANGER
BT-474	Growth Inhibition Assay				IC50=6.233 Î¼M	SANGER
BFTC-909	Growth Inhibition Assay				IC50=6.30345 Î¼M	SANGER
NB12	Growth Inhibition Assay				IC50=6.39071 Î¼M	SANGER
D-263MG	Growth Inhibition Assay				IC50=6.45169 Î¼M	SANGER
SNB75	Growth Inhibition Assay				IC50=6.60143 Î¼M	SANGER
A704	Growth Inhibition Assay				IC50=6.6306 Î¼M	SANGER
NCI-H1693	Growth Inhibition Assay				IC50=6.63604 Î¼M	SANGER
LN-405	Growth Inhibition Assay				IC50=6.79672 Î¼M	SANGER
CHL-1	Growth Inhibition Assay				IC50=6.80079 Î¼M	SANGER
A498	Growth Inhibition Assay				IC50=6.81961 Î¼M	SANGER
TE-12	Growth Inhibition Assay				IC50=6.83817 Î¼M	SANGER
TE-6	Growth Inhibition Assay				IC50=6.93038 Î¼M	SANGER
AU565	Growth Inhibition Assay				IC50=6.96957 Î¼M	SANGER
RD	Growth Inhibition Assay				IC50=6.98284 Î¼M	SANGER
SW1463	Growth Inhibition Assay				IC50=7.11168 Î¼M	SANGER
LU-99A	Growth Inhibition Assay				IC50=7.14322 Î¼M	SANGER
NCI-H28	Growth Inhibition Assay				IC50=7.2924 Î¼M	SANGER
MC-IXC	Growth Inhibition Assay				IC50=7.48576 Î¼M	SANGER
GP5d	Growth Inhibition Assay				IC50=7.48764 Î¼M	SANGER
GB-1	Growth Inhibition Assay				IC50=7.54804 Î¼M	SANGER
CAL-33	Growth Inhibition Assay				IC50=7.66233 Î¼M	SANGER
MSTO-211H	Growth Inhibition Assay				IC50=7.67336 Î¼M	SANGER
TE-5	Growth Inhibition Assay				IC50=7.79334 Î¼M	SANGER
D-566MG	Growth Inhibition Assay				IC50=8.04429 Î¼M	SANGER
JVM-3	Growth Inhibition Assay				IC50=8.15268 Î¼M	SANGER
T98G	Growth Inhibition Assay				IC50=8.18067 Î¼M	SANGER
HCC1954	Growth Inhibition Assay				IC50=8.45104 Î¼M	SANGER
SF126	Growth Inhibition Assay				IC50=8.45936 Î¼M	SANGER
LB996-RCC	Growth Inhibition Assay				IC50=8.53257 Î¼M	SANGER
SKG-IIIa	Growth Inhibition Assay				IC50=8.63069 Î¼M	SANGER
NCI-SNU-1	Growth Inhibition Assay				IC50=8.64643 Î¼M	SANGER
LB771-HNC	Growth Inhibition Assay				IC50=8.64696 Î¼M	SANGER
SCC-4	Growth Inhibition Assay				IC50=8.68219 Î¼M	SANGER
CAMA-1	Growth Inhibition Assay				IC50=8.77146 Î¼M	SANGER
D-502MG	Growth Inhibition Assay				IC50=8.78629 Î¼M	SANGER
ESS-1	Growth Inhibition Assay				IC50=8.88704 Î¼M	SANGER
HEC-1	Growth Inhibition Assay				IC50=8.89866 Î¼M	SANGER
NB10	Growth Inhibition Assay				IC50=9.02224 Î¼M	SANGER
8505C	Growth Inhibition Assay				IC50=9.04232 Î¼M	SANGER
EFO-27	Growth Inhibition Assay				IC50=9.16412 Î¼M	SANGER
HN	Growth Inhibition Assay				IC50=9.16628 Î¼M	SANGER
DSH1	Growth Inhibition Assay				IC50=9.2087 Î¼M	SANGER
NBsusSR	Growth Inhibition Assay				IC50=9.27402 Î¼M	SANGER
LS-123	Growth Inhibition Assay				IC50=9.31761 Î¼M	SANGER
SHP-77	Growth Inhibition Assay				IC50=9.39935 Î¼M	SANGER
ACN	Growth Inhibition Assay				IC50=9.53277 Î¼M	SANGER
U251	Growth Inhibition Assay				IC50=9.65544 Î¼M	SANGER
A431	Growth Inhibition Assay				IC50=9.80238 Î¼M	SANGER
5637	Growth Inhibition Assay				IC50=9.84984 Î¼M	SANGER
MDA-MB-157	Growth Inhibition Assay				IC50=9.92878 Î¼M	SANGER
A101D	Growth Inhibition Assay				IC50=9.99974 Î¼M	SANGER
YKG-1	Growth Inhibition Assay				IC50=10.2006 Î¼M	SANGER
LAN-6	Growth Inhibition Assay				IC50=10.2164 Î¼M	SANGER
OVCAR-5	Growth Inhibition Assay				IC50=10.2433 Î¼M	SANGER
A549	Growth Inhibition Assay				IC50=10.3973 Î¼M	SANGER
no-11	Growth Inhibition Assay				IC50=10.4353 Î¼M	SANGER
SF539	Growth Inhibition Assay				IC50=10.9041 Î¼M	SANGER
A388	Growth Inhibition Assay				IC50=11.3897 Î¼M	SANGER
DEL	Growth Inhibition Assay				IC50=11.424 Î¼M	SANGER
SW954	Growth Inhibition Assay				IC50=11.4668 Î¼M	SANGER
TK10	Growth Inhibition Assay				IC50=11.5271 Î¼M	SANGER
SW756	Growth Inhibition Assay				IC50=11.5294 Î¼M	SANGER
PC-3	Growth Inhibition Assay				IC50=11.5764 Î¼M	SANGER
ONS-76	Growth Inhibition Assay				IC50=11.636 Î¼M	SANGER
A427	Growth Inhibition Assay				IC50=11.7093 Î¼M	SANGER
MEG-01	Growth Inhibition Assay				IC50=11.7509 Î¼M	SANGER
BB30-HNC	Growth Inhibition Assay				IC50=11.7982 Î¼M	SANGER
NCI-H1299	Growth Inhibition Assay				IC50=11.8093 Î¼M	SANGER
GCT	Growth Inhibition Assay				IC50=11.8228 Î¼M	SANGER
D-247MG	Growth Inhibition Assay				IC50=11.9663 Î¼M	SANGER
CFPAC-1	Growth Inhibition Assay				IC50=11.9782 Î¼M	SANGER
EKVX	Growth Inhibition Assay				IC50=12.0313 Î¼M	SANGER
CAL-51	Growth Inhibition Assay				IC50=12.0716 Î¼M	SANGER
BB49-HNC	Growth Inhibition Assay				IC50=12.1177 Î¼M	SANGER
RPMI-7951	Growth Inhibition Assay				IC50=12.1854 Î¼M	SANGER
RH-1	Growth Inhibition Assay				IC50=12.2184 Î¼M	SANGER
BCPAP	Growth Inhibition Assay				IC50=12.4749 Î¼M	SANGER
GCIY	Growth Inhibition Assay				IC50=12.5209 Î¼M	SANGER
KNS-81-FD	Growth Inhibition Assay				IC50=12.5869 Î¼M	SANGER
KYSE-140	Growth Inhibition Assay				IC50=12.8595 Î¼M	SANGER
Ca-Ski	Growth Inhibition Assay				IC50=12.9041 Î¼M	SANGER
TGBC1TKB	Growth Inhibition Assay				IC50=12.9115 Î¼M	SANGER
HCC1187	Growth Inhibition Assay				IC50=13.1912 Î¼M	SANGER
SJSA-1	Growth Inhibition Assay				IC50=13.2327 Î¼M	SANGER
CTV-1	Growth Inhibition Assay				IC50=13.345 Î¼M	SANGER
WM-115	Growth Inhibition Assay				IC50=13.6483 Î¼M	SANGER
CHP-212	Growth Inhibition Assay				IC50=13.9739 Î¼M	SANGER
SCC-15	Growth Inhibition Assay				IC50=13.9775 Î¼M	SANGER
BPH-1	Growth Inhibition Assay				IC50=14.1664 Î¼M	SANGER
SW780	Growth Inhibition Assay				IC50=14.5025 Î¼M	SANGER
NCI-H2291	Growth Inhibition Assay				IC50=14.5878 Î¼M	SANGER
JEG-3	Growth Inhibition Assay				IC50=14.6326 Î¼M	SANGER
CAL-120	Growth Inhibition Assay				IC50=14.7027 Î¼M	SANGER
NCI-H23	Growth Inhibition Assay				IC50=14.7997 Î¼M	SANGER
MS-1	Growth Inhibition Assay				IC50=14.9611 Î¼M	SANGER
PC-14	Growth Inhibition Assay				IC50=14.9654 Î¼M	SANGER
D-283MED	Growth Inhibition Assay				IC50=15.0111 Î¼M	SANGER
OE19	Growth Inhibition Assay				IC50=15.1541 Î¼M	SANGER
CAS-1	Growth Inhibition Assay				IC50=15.4184 Î¼M	SANGER
NCI-H727	Growth Inhibition Assay				IC50=15.4221 Î¼M	SANGER
SiHa	Growth Inhibition Assay				IC50=15.7594 Î¼M	SANGER
BFTC-905	Growth Inhibition Assay				IC50=15.7694 Î¼M	SANGER
MDA-MB-453	Growth Inhibition Assay				IC50=16.1642 Î¼M	SANGER
HuP-T3	Growth Inhibition Assay				IC50=16.6373 Î¼M	SANGER
SK-LU-1	Growth Inhibition Assay				IC50=16.6956 Î¼M	SANGER
Detroit562	Growth Inhibition Assay				IC50=16.7318 Î¼M	SANGER
HCC1569	Growth Inhibition Assay				IC50=16.8337 Î¼M	SANGER
SK-MES-1	Growth Inhibition Assay				IC50=16.8419 Î¼M	SANGER
BB65-RCC	Growth Inhibition Assay				IC50=17.0479 Î¼M	SANGER
LOXIMVI	Growth Inhibition Assay				IC50=17.0707 Î¼M	SANGER
SW1783	Growth Inhibition Assay				IC50=17.128 Î¼M	SANGER
NH-12	Growth Inhibition Assay				IC50=17.3303 Î¼M	SANGER
UACC-257	Growth Inhibition Assay				IC50=17.5512 Î¼M	SANGER
KOSC-2	Growth Inhibition Assay				IC50=17.6757 Î¼M	SANGER
KG-1	Growth Inhibition Assay				IC50=17.6937 Î¼M	SANGER
M059J	Growth Inhibition Assay				IC50=17.703 Î¼M	SANGER
MHH-NB-11	Growth Inhibition Assay				IC50=17.9673 Î¼M	SANGER
EW-1	Growth Inhibition Assay				IC50=18.1382 Î¼M	SANGER
CAL-85-1	Growth Inhibition Assay				IC50=18.2357 Î¼M	SANGER
639-V	Growth Inhibition Assay				IC50=18.3354 Î¼M	SANGER
C32	Growth Inhibition Assay				IC50=18.4727 Î¼M	SANGER
KM-H2	Growth Inhibition Assay				IC50=18.5232 Î¼M	SANGER
A253	Growth Inhibition Assay				IC50=18.7286 Î¼M	SANGER
NCI-N87	Growth Inhibition Assay				IC50=18.9008 Î¼M	SANGER
8-MG-BA	Growth Inhibition Assay				IC50=19.0646 Î¼M	SANGER
GI-ME-N	Growth Inhibition Assay				IC50=19.1546 Î¼M	SANGER
8305C	Growth Inhibition Assay				IC50=19.2286 Î¼M	SANGER
TE-8	Growth Inhibition Assay				IC50=19.3024 Î¼M	SANGER
KYSE-270	Growth Inhibition Assay				IC50=20.0217 Î¼M	SANGER
HL-60	Growth Inhibition Assay				IC50=20.0941 Î¼M	SANGER
Mo-T	Growth Inhibition Assay				IC50=20.1665 Î¼M	SANGER
NCI-H1355	Growth Inhibition Assay				IC50=20.3374 Î¼M	SANGER
HT-1080	Growth Inhibition Assay				IC50=20.5497 Î¼M	SANGER
MIA-PaCa-2	Growth Inhibition Assay				IC50=20.6883 Î¼M	SANGER
NCI-H441	Growth Inhibition Assay				IC50=20.7379 Î¼M	SANGER
LCLC-97TM1	Growth Inhibition Assay				IC50=20.8134 Î¼M	SANGER
HT-3	Growth Inhibition Assay				IC50=21.5631 Î¼M	SANGER
22RV1	Growth Inhibition Assay				IC50=21.5685 Î¼M	SANGER
LK-2	Growth Inhibition Assay				IC50=21.5953 Î¼M	SANGER
CW-2	Growth Inhibition Assay				IC50=21.6069 Î¼M	SANGER
KYSE-510	Growth Inhibition Assay				IC50=21.6095 Î¼M	SANGER
CGTH-W-1	Growth Inhibition Assay				IC50=21.7166 Î¼M	SANGER
NCI-H661	Growth Inhibition Assay				IC50=22.034 Î¼M	SANGER
KU-19-19	Growth Inhibition Assay				IC50=22.1697 Î¼M	SANGER
NCI-H2122	Growth Inhibition Assay				IC50=22.2432 Î¼M	SANGER
NCI-H526	Growth Inhibition Assay				IC50=22.3895 Î¼M	SANGER
NCI-H1650	Growth Inhibition Assay				IC50=22.764 Î¼M	SANGER
AM-38	Growth Inhibition Assay				IC50=22.8689 Î¼M	SANGER
NCI-H2405	Growth Inhibition Assay				IC50=23.2533 Î¼M	SANGER
M14	Growth Inhibition Assay				IC50=23.4088 Î¼M	SANGER
ES4	Growth Inhibition Assay				IC50=23.4232 Î¼M	SANGER
DJM-1	Growth Inhibition Assay				IC50=23.5234 Î¼M	SANGER
S-117	Growth Inhibition Assay				IC50=23.7651 Î¼M	SANGER
MZ2-MEL	Growth Inhibition Assay				IC50=23.7759 Î¼M	SANGER
SK-MEL-2	Growth Inhibition Assay				IC50=23.8133 Î¼M	SANGER
HCC1806	Growth Inhibition Assay				IC50=23.8709 Î¼M	SANGER
NMC-G1	Growth Inhibition Assay				IC50=24.2226 Î¼M	SANGER
DK-MG	Growth Inhibition Assay				IC50=24.294 Î¼M	SANGER
SK-N-FI	Growth Inhibition Assay				IC50=24.3302 Î¼M	SANGER
KINGS-1	Growth Inhibition Assay				IC50=24.4874 Î¼M	SANGER
HCC2998	Growth Inhibition Assay				IC50=24.4885 Î¼M	SANGER
ALL-PO	Growth Inhibition Assay				IC50=24.619 Î¼M	SANGER
MPP-89	Growth Inhibition Assay				IC50=25.0458 Î¼M	SANGER
NCI-H2342	Growth Inhibition Assay				IC50=25.1953 Î¼M	SANGER
TE-1	Growth Inhibition Assay				IC50=25.3563 Î¼M	SANGER
RH-18	Growth Inhibition Assay				IC50=25.5918 Î¼M	SANGER
HT-1376	Growth Inhibition Assay				IC50=25.6465 Î¼M	SANGER
U-2-OS	Growth Inhibition Assay				IC50=25.6888 Î¼M	SANGER
BT-549	Growth Inhibition Assay				IC50=25.9011 Î¼M	SANGER
NCI-H1755	Growth Inhibition Assay				IC50=25.9945 Î¼M	SANGER
EW-13	Growth Inhibition Assay				IC50=26.0274 Î¼M	SANGER
NB13	Growth Inhibition Assay				IC50=26.0949 Î¼M	SANGER
NUGC-3	Growth Inhibition Assay				IC50=26.2103 Î¼M	SANGER
GMS-10	Growth Inhibition Assay				IC50=26.2353 Î¼M	SANGER
CHP-134	Growth Inhibition Assay				IC50=26.3867 Î¼M	SANGER
SW962	Growth Inhibition Assay				IC50=26.5021 Î¼M	SANGER
SNU-449	Growth Inhibition Assay				IC50=27.0803 Î¼M	SANGER
HuP-T4	Growth Inhibition Assay				IC50=27.0879 Î¼M	SANGER
SW948	Growth Inhibition Assay				IC50=27.1344 Î¼M	SANGER
NCI-H226	Growth Inhibition Assay				IC50=27.4578 Î¼M	SANGER
SK-PN-DW	Growth Inhibition Assay				IC50=27.6012 Î¼M	SANGER
GI-1	Growth Inhibition Assay				IC50=27.721 Î¼M	SANGER
CAL-12T	Growth Inhibition Assay				IC50=28.1112 Î¼M	SANGER
YAPC	Growth Inhibition Assay				IC50=28.2564 Î¼M	SANGER
SNU-C2B	Growth Inhibition Assay				IC50=28.2964 Î¼M	SANGER
RCC10RGB	Growth Inhibition Assay				IC50=28.5417 Î¼M	SANGER
ES7	Growth Inhibition Assay				IC50=29.1465 Î¼M	SANGER
PANC-03-27	Growth Inhibition Assay				IC50=29.444 Î¼M	SANGER
ES6	Growth Inhibition Assay				IC50=29.8157 Î¼M	SANGER
HT-1197	Growth Inhibition Assay				IC50=30.0598 Î¼M	SANGER
ZR-75-30	Growth Inhibition Assay				IC50=30.2383 Î¼M	SANGER
DB	Growth Inhibition Assay				IC50=30.4942 Î¼M	SANGER
OCI-AML2	Growth Inhibition Assay				IC50=31.069 Î¼M	SANGER
NCI-H2170	Growth Inhibition Assay				IC50=31.8516 Î¼M	SANGER
IST-MES1	Growth Inhibition Assay				IC50=32.2897 Î¼M	SANGER
769-P	Growth Inhibition Assay				IC50=32.3641 Î¼M	SANGER
COR-L23	Growth Inhibition Assay				IC50=32.9073 Î¼M	SANGER
SW626	Growth Inhibition Assay				IC50=33.1776 Î¼M	SANGER
LU-139	Growth Inhibition Assay				IC50=33.6605 Î¼M	SANGER
HT-144	Growth Inhibition Assay				IC50=33.863 Î¼M	SANGER
CaR-1	Growth Inhibition Assay				IC50=33.9822 Î¼M	SANGER
OE33	Growth Inhibition Assay				IC50=34.2855 Î¼M	SANGER
COLO-800	Growth Inhibition Assay				IC50=34.3647 Î¼M	SANGER
NB14	Growth Inhibition Assay				IC50=34.4684 Î¼M	SANGER
KURAMOCHI	Growth Inhibition Assay				IC50=36.1198 Î¼M	SANGER
SW48	Growth Inhibition Assay				IC50=36.2474 Î¼M	SANGER
Daoy	Growth Inhibition Assay				IC50=36.6538 Î¼M	SANGER
TGBC24TKB	Growth Inhibition Assay				IC50=36.67 Î¼M	SANGER
DU-4475	Growth Inhibition Assay				IC50=36.9033 Î¼M	SANGER
SW1417	Growth Inhibition Assay				IC50=38.0552 Î¼M	SANGER
EFO-21	Growth Inhibition Assay				IC50=38.9349 Î¼M	SANGER
MG-63	Growth Inhibition Assay				IC50=39.3424 Î¼M	SANGER
LC-2-ad	Growth Inhibition Assay				IC50=39.5512 Î¼M	SANGER
NOMO-1	Growth Inhibition Assay				IC50=39.8274 Î¼M	SANGER
COLO-741	Growth Inhibition Assay				IC50=40.1304 Î¼M	SANGER
BxPC-3	Growth Inhibition Assay				IC50=40.5686 Î¼M	SANGER
HSC-2	Growth Inhibition Assay				IC50=40.9113 Î¼M	SANGER
UMC-11	Growth Inhibition Assay				IC50=41.263 Î¼M	SANGER
HCC1937	Growth Inhibition Assay				IC50=42.7843 Î¼M	SANGER
Calu-6	Growth Inhibition Assay				IC50=43.2382 Î¼M	SANGER
NCI-H1573	Growth Inhibition Assay				IC50=43.3477 Î¼M	SANGER
SK-N-AS	Growth Inhibition Assay				IC50=43.6019 Î¼M	SANGER
PSN1	Growth Inhibition Assay				IC50=45.2548 Î¼M	SANGER
TE-11	Growth Inhibition Assay				IC50=45.4842 Î¼M	SANGER
NCI-H1155	Growth Inhibition Assay				IC50=45.8967 Î¼M	SANGER
KM12	Growth Inhibition Assay				IC50=45.9076 Î¼M	SANGER
RO82-W-1	Growth Inhibition Assay				IC50=46.9822 Î¼M	SANGER
SW1573	Growth Inhibition Assay				IC50=47.3736 Î¼M	SANGER
CAKI-1	Growth Inhibition Assay				IC50=48.2845 Î¼M	SANGER
U-118-MG	Growth Inhibition Assay				IC50=48.3702 Î¼M	SANGER
KYSE-520	Growth Inhibition Assay				IC50=48.4016 Î¼M	SANGER
HT55	Growth Inhibition Assay				IC50=49.1474 Î¼M	SANGER
ChaGo-K-1	Growth Inhibition Assay				IC50=49.4793 Î¼M	SANGER
IA-LM	Growth Inhibition Assay				IC50=54.6322 Î¼M	SANGER
UACC-62	Growth Inhibition Assay				IC50=55.1046 Î¼M	SANGER
MKN7	Growth Inhibition Assay				IC50=56.0285 Î¼M	SANGER
HPAF-II	Growth Inhibition Assay				IC50=56.4073 Î¼M	SANGER
NTERA-S-cl-D1	Growth Inhibition Assay				IC50=57.778 Î¼M	SANGER
FTC-133	Growth Inhibition Assay				IC50=58.0969 Î¼M	SANGER
MHH-ES-1	Growth Inhibition Assay				IC50=58.4814 Î¼M	SANGER
JVM-2	Growth Inhibition Assay				IC50=58.9506 Î¼M	SANGER
TCCSUP	Growth Inhibition Assay				IC50=59.5279 Î¼M	SANGER
COLO-824	Growth Inhibition Assay				IC50=60.0719 Î¼M	SANGER
647-V	Growth Inhibition Assay				IC50=60.1347 Î¼M	SANGER
HD-MY-Z	Growth Inhibition Assay				IC50=60.5294 Î¼M	SANGER
LS-411N	Growth Inhibition Assay				IC50=61.3903 Î¼M	SANGER
NCI-H596	Growth Inhibition Assay				IC50=62.7496 Î¼M	SANGER
C-33-A	Growth Inhibition Assay				IC50=64.0957 Î¼M	SANGER
BHY	Growth Inhibition Assay				IC50=64.1245 Î¼M	SANGER
KGN	Growth Inhibition Assay				IC50=64.5514 Î¼M	SANGER
NCI-H1092	Growth Inhibition Assay				IC50=65.0095 Î¼M	SANGER
MZ1-PC	Growth Inhibition Assay				IC50=65.5649 Î¼M	SANGER
LB831-BLC	Growth Inhibition Assay				IC50=65.8481 Î¼M	SANGER
SW620	Growth Inhibition Assay				IC50=66.2039 Î¼M	SANGER
HuO-3N1	Growth Inhibition Assay				IC50=68.3238 Î¼M	SANGER
SK-HEP-1	Growth Inhibition Assay				IC50=69.9486 Î¼M	SANGER
LCLC-103H	Growth Inhibition Assay				IC50=70.6705 Î¼M	SANGER
KYSE-70	Growth Inhibition Assay				IC50=70.7835 Î¼M	SANGER
Mewo	Growth Inhibition Assay				IC50=71.505 Î¼M	SANGER
COLO-668	Growth Inhibition Assay				IC50=71.8451 Î¼M	SANGER
NCI-H522	Growth Inhibition Assay				IC50=72.3413 Î¼M	SANGER
NCI-H1437	Growth Inhibition Assay				IC50=74.4048 Î¼M	SANGER
U-266	Growth Inhibition Assay				IC50=75.4516 Î¼M	SANGER
MC116	Growth Inhibition Assay				IC50=75.5708 Î¼M	SANGER
PANC-10-05	Growth Inhibition Assay				IC50=77.4243 Î¼M	SANGER
KYSE-180	Growth Inhibition Assay				IC50=77.5454 Î¼M	SANGER
JAR	Growth Inhibition Assay				IC50=79.0546 Î¼M	SANGER
CAL-62	Growth Inhibition Assay				IC50=80.095 Î¼M	SANGER
A3-KAW	Growth Inhibition Assay				IC50=80.2154 Î¼M	SANGER
PANC-08-13	Growth Inhibition Assay				IC50=81.1768 Î¼M	SANGER
HSC-3	Growth Inhibition Assay				IC50=83.3071 Î¼M	SANGER
HTC-C3	Growth Inhibition Assay				IC50=83.4702 Î¼M	SANGER
KY821	Growth Inhibition Assay				IC50=84.0892 Î¼M	SANGER
DoTc2-4510	Growth Inhibition Assay				IC50=84.2185 Î¼M	SANGER
NCI-H1581	Growth Inhibition Assay				IC50=85.4641 Î¼M	SANGER
KARPAS-299	Growth Inhibition Assay				IC50=86.1977 Î¼M	SANGER
IST-MEL1	Growth Inhibition Assay				IC50=86.8872 Î¼M	SANGER
KP-N-YS	Growth Inhibition Assay				IC50=89.9028 Î¼M	SANGER
KYSE-410	Growth Inhibition Assay				IC50=91.4042 Î¼M	SANGER
TE-10	Growth Inhibition Assay				IC50=91.5611 Î¼M	SANGER
SK-MEL-1	Growth Inhibition Assay				IC50=92.9106 Î¼M	SANGER
COLO-792	Growth Inhibition Assay				IC50=95.2564 Î¼M	SANGER
SCH	Growth Inhibition Assay				IC50=96.3877 Î¼M	SANGER
NCI-H1792	Growth Inhibition Assay				IC50=96.8992 Î¼M	SANGER
NCI-H2029	Growth Inhibition Assay				IC50=96.9566 Î¼M	SANGER
SW684	Growth Inhibition Assay				IC50=98.6654 Î¼M	SANGER
NCI-H209	Growth Inhibition Assay				IC50=100.121 Î¼M	SANGER
HLE	Growth Inhibition Assay				IC50=105.282 Î¼M	SANGER
GOTO	Growth Inhibition Assay				IC50=107.777 Î¼M	SANGER
NCI-H1793	Growth Inhibition Assay				IC50=109.28 Î¼M	SANGER
D-392MG	Growth Inhibition Assay				IC50=117.398 Î¼M	SANGER
SW1990	Growth Inhibition Assay				IC50=120.951 Î¼M	SANGER
ML-2	Growth Inhibition Assay				IC50=121.676 Î¼M	SANGER
NCI-H2452	Growth Inhibition Assay				IC50=122.21 Î¼M	SANGER
SK-MEL-30	Growth Inhibition Assay				IC50=123.244 Î¼M	SANGER
SN12C	Growth Inhibition Assay				IC50=124.176 Î¼M	SANGER
NCI-H1770	Growth Inhibition Assay				IC50=125.514 Î¼M	SANGER
SF268	Growth Inhibition Assay				IC50=126.158 Î¼M	SANGER
BALL-1	Growth Inhibition Assay				IC50=126.23 Î¼M	SANGER
COLO-679	Growth Inhibition Assay				IC50=126.753 Î¼M	SANGER
A2780	Growth Inhibition Assay				IC50=128.988 Î¼M	SANGER
NCI-H1651	Growth Inhibition Assay				IC50=131.243 Î¼M	SANGER
NCI-H2087	Growth Inhibition Assay				IC50=131.483 Î¼M	SANGER
U-87-MG	Growth Inhibition Assay				IC50=133.604 Î¼M	SANGER
LB2518-MEL	Growth Inhibition Assay				IC50=135.993 Î¼M	SANGER
HCT-116	Growth Inhibition Assay				IC50=137.217 Î¼M	SANGER
Ca9-22	Growth Inhibition Assay				IC50=139.833 Î¼M	SANGER
COR-L88	Growth Inhibition Assay				IC50=142.14 Î¼M	SANGER
CP50-MEL-B	Growth Inhibition Assay				IC50=144.501 Î¼M	SANGER
OVCAR-8	Growth Inhibition Assay				IC50=145.636 Î¼M	SANGER
SK-MEL-3	Growth Inhibition Assay				IC50=147.878 Î¼M	SANGER
GT3TKB	Growth Inhibition Assay				IC50=149.928 Î¼M	SANGER
KYSE-450	Growth Inhibition Assay				IC50=151.539 Î¼M	SANGER
CAPAN-1	Growth Inhibition Assay				IC50=153.064 Î¼M	SANGER
BEN	Growth Inhibition Assay				IC50=153.928 Î¼M	SANGER
NCI-H1304	Growth Inhibition Assay				IC50=154.694 Î¼M	SANGER
KU812	Growth Inhibition Assay				IC50=158.674 Î¼M	SANGER
Capan-2	Growth Inhibition Assay				IC50=160.553 Î¼M	SANGER
A673	Growth Inhibition Assay				IC50=161.705 Î¼M	SANGER
SAS	Growth Inhibition Assay				IC50=162.678 Î¼M	SANGER
NY	Growth Inhibition Assay				IC50=165.314 Î¼M	SANGER
HCE-4	Growth Inhibition Assay				IC50=166.845 Î¼M	SANGER
MDA-MB-231	Growth Inhibition Assay				IC50=177.503 Î¼M	SANGER
no-10	Growth Inhibition Assay				IC50=178.134 Î¼M	SANGER
MZ7-mel	Growth Inhibition Assay				IC50=178.467 Î¼M	SANGER
NCI-H82	Growth Inhibition Assay				IC50=180.165 Î¼M	SANGER
CAL-72	Growth Inhibition Assay				IC50=185.054 Î¼M	SANGER
NCI-SNU-5	Growth Inhibition Assay				IC50=186.84 Î¼M	SANGER
OVCAR-4	Growth Inhibition Assay				IC50=188.333 Î¼M	SANGER
SCC-9	Growth Inhibition Assay				IC50=191 Î¼M	SANGER
KYSE-150	Growth Inhibition Assay				IC50=191.888 Î¼M	SANGER
HT-29	Growth Inhibition Assay				IC50=201.212 Î¼M	SANGER
COLO-678	Growth Inhibition Assay				IC50=201.45 Î¼M	SANGER
NCI-H650	Growth Inhibition Assay				IC50=202.103 Î¼M	SANGER
HuCCT1	Growth Inhibition Assay				IC50=204.208 Î¼M	SANGER
SW1116	Growth Inhibition Assay				IC50=207.077 Î¼M	SANGER
DBTRG-05MG	Growth Inhibition Assay				IC50=207.909 Î¼M	SANGER
SW982	Growth Inhibition Assay				IC50=207.948 Î¼M	SANGER
RCM-1	Growth Inhibition Assay				IC50=214.762 Î¼M	SANGER
COLO-320-HSR	Growth Inhibition Assay				IC50=216.125 Î¼M	SANGER
KNS-42	Growth Inhibition Assay				IC50=216.574 Î¼M	SANGER
C2BBe1	Growth Inhibition Assay				IC50=231.905 Î¼M	SANGER
CCRF-CEM	Growth Inhibition Assay				IC50=243.795 Î¼M	SANGER
SH-4	Growth Inhibition Assay				IC50=246.09 Î¼M	SANGER
LS-1034	Growth Inhibition Assay				IC50=246.266 Î¼M	SANGER
NCI-H2347	Growth Inhibition Assay				IC50=247.713 Î¼M	SANGER
RPMI-8866	Growth Inhibition Assay				IC50=249.27 Î¼M	SANGER
GAK	Growth Inhibition Assay				IC50=253.002 Î¼M	SANGER
NB6	Growth Inhibition Assay				IC50=270.1 Î¼M	SANGER
COLO-680N	Growth Inhibition Assay				IC50=272.527 Î¼M	SANGER
RERF-LC-MS	Growth Inhibition Assay				IC50=276.007 Î¼M	SANGER
TGBC11TKB	Growth Inhibition Assay				IC50=278.178 Î¼M	SANGER
C8166	Growth Inhibition Assay				IC50=278.506 Î¼M	SANGER
HDLM-2	Growth Inhibition Assay				IC50=294.409 Î¼M	SANGER
IGR-1	Growth Inhibition Assay				IC50=295.659 Î¼M	SANGER
FADU	Growth Inhibition Assay				IC50=297.51 Î¼M	SANGER
L-428	Growth Inhibition Assay				IC50=297.616 Î¼M	SANGER
LU-65	Growth Inhibition Assay				IC50=304.32 Î¼M	SANGER
HEL	Growth Inhibition Assay				IC50=309.983 Î¼M	SANGER
NCI-H810	Growth Inhibition Assay				IC50=310.57 Î¼M	SANGER
C3A	Growth Inhibition Assay				IC50=311.802 Î¼M	SANGER
NCI-H630	Growth Inhibition Assay				IC50=332.294 Î¼M	SANGER
KP-N-YN	Growth Inhibition Assay				IC50=341.123 Î¼M	SANGER
MOLT-13	Growth Inhibition Assay				IC50=342.326 Î¼M	SANGER
NCI-H1993	Growth Inhibition Assay				IC50=342.365 Î¼M	SANGER
BE-13	Growth Inhibition Assay				IC50=344.167 Î¼M	SANGER
IST-SL1	Growth Inhibition Assay				IC50=347.401 Î¼M	SANGER
TE-9	Growth Inhibition Assay				IC50=363.589 Î¼M	SANGER
LU-135	Growth Inhibition Assay				IC50=367.035 Î¼M	SANGER
T84	Growth Inhibition Assay				IC50=374.712 Î¼M	SANGER
K-562	Growth Inhibition Assay				IC50=383.36 Î¼M	SANGER
SBC-5	Growth Inhibition Assay				IC50=386.985 Î¼M	SANGER
NB17	Growth Inhibition Assay				IC50=392.596 Î¼M	SANGER
NCI-H2052	Growth Inhibition Assay				IC50=398.472 Î¼M	SANGER
HCC38	Growth Inhibition Assay				IC50=401.593 Î¼M	SANGER
NCI-H69	Growth Inhibition Assay				IC50=441.083 Î¼M	SANGER

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In vivo

MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. ^[1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. ^[2]