IOWH-032
(CAS No:1191252-49-9)
QC Documents
ChemicalInfomation
| CAS No: |
1191252-49-9 |
| Molecular formula(MF) |
C22H15Br2N3O4 |
| Molecular Weight(MW): |
545.18 |
| Alias |
|
Solubility
| In vitro |
DMSO
|
100 mg/mL
(183.42 mM)
|
|
Water
|
<1 mg/mL
|
|
Ethanol
|
<1 mg/mL
|
| In vivo |
|
|
Biological Activity
| Description |
IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 2. |
|
Targets
|
|
| In vitro |
IOWH032 shows inhibitory activity against CFTR in T84-CFTR cell based assays with IC50 of 6.87 μM. [1]
|
| In vivo |
In a mouse closed-loop model, IOWH032 causes a statistical significant inhibition against cholera toxin (CTX) induced secretion. IOWH032 (5 mg/kg) reduces the fecal output index by ~70% in a cecetomized rat model. [1]
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COA
HPLC