 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 1246529-32-7 |
| Molecular formula(MF) | C22H29N7O |
| Molecular Weight(MW): | 407.51 |
| Alias |
| In vitro | DMSO | 62 mg/mL warmed (152.14 mM) |
|---|---|---|
| Ethanol | 2 mg/mL warmed (4.9 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases. | ||
|---|---|---|---|
| Targets |
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| In vitro |
MPI-0479605 impairs the SAC and the bipolar attachment of chromosomes to the mitotic spindle, which results in chromosome segregation defects and aneuploidy. MPI-0479605 results in a significant decrease in cell viability with GI50 ranging from 30 to 100 nM in a panel of tumor cell lines. In addition, MPI-0479605 also causes cell growth arrest and ultimately promotes cell death by apoptosis or mitotic catastrophe. [1] |
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| In vivo | MPI-0479605 (30 mg/kg daily or 150 mg/kg every 4 days, i.p.) shows antitumor activity in colon cancer xenograft models. [1] |