 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 1297538-32-9 |
| Molecular formula(MF) | C19H19ClN6O2 |
| Molecular Weight(MW): | 398.85 |
| Alias |
| In vitro | DMSO | 80 mg/mL (200.57 mM) |
|---|---|---|
| Ethanol | 38 mg/mL warmed (95.27 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | ODM-201 is a novel androgen receptor (AR) antagonist that blocks AR nuclear translocation with Ki of 11 nM. Phase 3. | ||
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| Targets |
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| In vitro |
In AR-HEK293 cells stably expressing full-length hAR, ODM-201 inhibits human AR (hAR) with IC50 of 26 nM. ODM-201 inhibits VCaP cell proliferation with IC50 of 230 nM, while has no effect on the viability of AR-negative cell lines tested, DU-145 prostate cancer cells and H1581 lung cancer cells. [1] |
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| In vivo | In mice bearing VCaP xenografts, ODM-201 (50 mg/kg, p.o.) significantly inhibits castration-resistant prostate tumor growth. [1] |