 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 130929-57-6 |
| Molecular formula(MF) | C14H15N3O5 |
| Molecular Weight(MW): | 305.29 |
| Alias | 2-cyano-3-(5-dihydroxyamino-3,4-dioxo-1-cyclohexa-1,5-dienyl)-n,n-diethyl-prop-2-enamide |
| In vitro | DMSO | 61 mg/mL (199.81 mM) |
|---|---|---|
| Ethanol | 2 mg/mL (6.55 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | Entacapone inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM. | ||
|---|---|---|---|
| Targets |
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| In vitro |
Entacapone inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. [1] Entacapone (< 100 μM) is a potent inhibitor of α-syn and β-amyloid (Aβ) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells. [2] |