 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 139180-30-6 |
| Molecular formula(MF) | C16H15N7O2 |
| Molecular Weight(MW): | 337.34 |
| Alias |
| In vitro | DMSO | 67 mg/mL (198.61 mM) |
|---|---|---|
| Water | <1 mg/mL | |
| Ethanol | <1 mg/mL | |
| In vivo |
| Description | ZM-241385 is a high affinity antagonist ligand selective for the adenosine A2A receptor. | |
|---|---|---|
| Targets |
|
|
| In vitro |
ZM 241385 has high affinity for A2a receptors. In rat phaeochromocytoma cell membranes, ZM 241385 displaces binding of tritiated 5'-N-ethylcarboxamidoadenosine (NECA) with a pIC50 of 9.52[3]. ZM241385 delays the appearance of anoxic depolarization (AD), a phenomenon strictly related to cell damage and death, protect from the synaptic activity depression brought about by a severe (7 min) OGD period, and protect CA1 neuron and astrocyte from injury[4]. |
|
| In vivo | ZM-241385 significantly blunts the hypotensive effects of CCPA and NECA without altering the bradycardia induced by these agonists. It blocks the infarct size-reducing effects(cardioprotective effects) of this two distinct adenosine receptor agonists[1]. |