 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 1395084-25-9 |
| Molecular formula(MF) | C18H17N5O3S |
| Molecular Weight(MW): | 383.42 |
| Alias |
| In vitro | DMSO | 55 mg/mL (143.44 mM) |
|---|---|---|
| Ethanol | 1 mg/mL warmed (2.6 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | MS436 is a selective BET bromodomain inhibitor with Ki of <0.085 μM and 0.34 μM for BRD4 (1) and BRD4 (2), respectively. | ||||
|---|---|---|---|---|---|
| Targets |
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| In vitro |
MS436 exhibits low nanomolar affinity with preference for the first bromodomain over the second. MS436 effectively inhibits BRD4 activity in NF-κB-directed production of nitric oxide and proinflammatory cytokine interleukin-6 in murine macrophages without siginificanty inhibition on cell viability. [1] |