 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 1418013-75-8 |
| Molecular formula(MF) | C27H28N4O3S2 |
| Molecular Weight(MW): | 520.67 |
| Alias |
| In vitro | DMSO | 100 mg/mL (192.06 mM) |
|---|---|---|
| Water | <1 mg/mL | |
| Ethanol | <1 mg/mL | |
| In vivo |
| Description | NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM). | ||
|---|---|---|---|
| Features | The most potent and specific p97 inhibitor described to date. | ||
| Targets |
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| In vitro |
NMS-873 reduces p97 sensitivity to trypsin digestion, preventing degradation of the linker-D2 domain. NMS-873, as a p97 inhibitor, produces antiproliferative activity in a variety of hematological and solid tumor lines. The mechanism study indicates that NMS-873 activates the unfolded protein response, interfers with autophagy and thus induces cancer cell death. [1] |