 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 1421227-53-3 |
| Molecular formula(MF) | C29H31F3N6O3 |
| Molecular Weight(MW): | 568.59 |
| Alias |
| In vitro | DMSO | 100 mg/mL (175.87 mM) |
|---|---|---|
| Ethanol | 100 mg/mL (175.87 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. | ||
|---|---|---|---|
| Targets |
|
||
| In vitro |
WS6 induces R7T1 cell proliferation with EC50 of 0.28 μM, and promotes β cell proliferation in rodent and human primary islets. Both Erb3 binding protein-1 and the IκB kinase pathway are confirmed to function in the mechanism of action of WS6. [1] |
||
| In vivo | In RIP-DTA mouse model of β cell ablation, WS6 (50 mg/kg p.o.) ameliorates diabetes, and induces concomitant increases in β cell proliferation and β cell number. [1] |