 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 1430844-80-6 |
| Molecular formula(MF) | C38H38N6O3S |
| Molecular Weight(MW): | 658.81 |
| Alias |
| In vitro | DMSO | 100 mg/mL (151.78 mM) |
|---|---|---|
| Water | <1 mg/mL | |
| Ethanol | <1 mg/mL | |
| In vivo |
| Description | A-1331852 is a potent and selectiveBCL-XL inhibitor and may be useful in the treatment of cancer, immune and autoimmune diseases. | ||||||||
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| Targets |
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| In vitro |
A-1331852 exhibits remarkable potency both as a single agent and in combination with TKIs in killing primary CD34+ CML cell. Also, It has remarkable potency in inducing apoptosis in these cells at low nanomolar concentrations as early as 1 h post-treatment[2]. |
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| In vivo | A-1331852 demonstrates antitumor efficacy in the Molt-4 xenograft model, inducing tumor regressions as a single agent[1]. |