 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 1432660-47-3 |
| Molecular formula(MF) | C21H18F3N3O3S2 |
| Molecular Weight(MW): | 481.51 |
| Alias |
| In vitro | DMSO | 96 mg/mL (199.37 mM) |
|---|---|---|
| Ethanol | 96 mg/mL (199.37 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM. | ||
|---|---|---|---|
| Targets |
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| In vitro |
AGI-6780 potently reduce (R)-2-hydroxyglutarate (2HG) levels in cell lines ectopically overexpressing IDH2/R140Q with EC50 of 20 nM, with excellent selectivity against other dehydrogenases. AGI-6780 reverses the IDH2/R140Q-induced differentiation block in TF-1 cells, and induces blast differentiation in primary human IDH2/R140Q AML patient samples. [1] |