 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 1477949-42-0 |
| Molecular formula(MF) | C15H22N2O3 |
| Molecular Weight(MW): | 278.35 |
| Alias |
| In vitro | DMSO | 55 mg/mL (197.59 mM) |
|---|---|---|
| Ethanol | 55 mg/mL (197.59 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | Santacruzamate A (CAY10683) is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2, >3600-fold selectivity over other HDACs. | ||||||
|---|---|---|---|---|---|---|---|
| Targets |
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| In vitro |
Santacruzamate A inhibits the growth of HCT116 colon carcinoma cells and HuT-78 cutaneous T-cell lymphoma cells, with GI50 values of 29.4 μM and 1.4 μM, respectively. However, Santacruzamate A shows hypotoxicity to human dermal fibroblast cells (GI50 >100 μM). [1] |