 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 1613724-42-7 |
| Molecular formula(MF) | C26H28N8O |
| Molecular Weight(MW): | 468.55 |
| Alias |
| In vitro | DMSO | 58 mg/mL warmed (123.78 mM) |
|---|---|---|
| Ethanol | 30 mg/mL (64.02 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | HTH-01-015 is a potent and selective NUAK1 inhibitor with IC50 of 100 nM, >100-fold selectivity over NUAK2. | ||||
|---|---|---|---|---|---|
| Targets |
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| In vitro |
In HEK-293 cells express NUAK1 as well as NUAK2, HTH-01-015 suppresses NUAK1-mediated MYPT1 phosphorylation. HTH-01-015 suppresses cell migration In NUAK1+/+ MEFs, and inhibit U2OS cell invasion. Moreover, HTH-01-015 inhibits cell proliferation in both cell lines. [1] HTH-01-015 inhibitors markedly restricted cells from entering into mitosis in U2OS cells. [2] |