 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 1616391-87-7 |
| Molecular formula(MF) | C22H28N4O2 |
| Molecular Weight(MW): | 380.48 |
| Alias |
| In vitro | DMSO | 76 mg/mL (199.74 mM) |
|---|---|---|
| Ethanol | 76 mg/mL (199.74 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | GSK591 (EPZ015866,GSK3203591) is a potent selective inhibitor of the arginine methyltransferase PRMT5 with IC50 of 11 nM. | ||
|---|---|---|---|
| Targets |
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| In vitro |
In an in vitro biochemical assay, GSK591 potently inhibits the PRMT5/MEP50 complex from methylating (histone) H4 with IC50 = 11 nM. In Z-138 cells, GSK591 inhibits the symmetric arginine methylation of SmD3 with EC50 = 56 nM. Further, GSK591 is selective for PRMT5 (up to 50 micromolar) relative to a panel of methyltransferases[2]. |