 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 1633044-56-0 |
| Molecular formula(MF) | C35H38N8O4 |
| Molecular Weight(MW): | 634.73 |
| Alias |
| In vitro | DMSO | 69 mg/mL (108.7 mM) |
|---|---|---|
| Water | <1 mg/mL | |
| Ethanol | <1 mg/mL | |
| In vivo |
| Description | FIIN-2 is an irreversible, pan-FGFR inhibitor with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM for FGFR1/2/3/4, respectively. | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Targets |
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| In vitro |
In FGFR1-4 Ba/F3 cells, FIIN-2 inhibits cell proliferation with EC50 in the single- to double-digit nanomolar range. FIIN-2 also shows excellent antiproliferative activity in a variety of backgrounds, including cell lines that have gatekeeper mutations in FGFR1 and that are dependent on FGFR4. [1] |
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| In vivo | In a zebrafish developmental model, FIIN-2 causes mild or severe phenotypes to the tail morphogenesis by inhibiting FGFR. [1] |