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OICR-9429

(CAS No:1801787-56-3)

OICR-9429 is a potent antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3 and reduces viability of acute myeloid leukemia cells in vitro.

CAS No:1801787-56-3

Molecular Weight(MW):555.59

Purity:99.00%

Specification:500MG;1G;5G;10G;50G;100G

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QC Documents

COA	MSDS	HPLC	NMR

ChemicalInfomation

CAS No:	1801787-56-3
Molecular formula(MF)	C₂₉H₃₂F₃N₅O₃
Molecular Weight(MW):	555.59
Alias

Solubility

In vitro	DMSO	38 mg/mL (68.39 mM)
	Ethanol	15 mg/mL (26.99 mM)
	Water	<1 mg/mL
In vivo

Biological Activity

Description

OICR-9429 is a potent antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3 and reduces viability of acute myeloid leukemia cells in vitro.

Targets

Wdr5-MLL interaction ^[1]	WDR5 ^[1]
	93 nM(Kd)

In vitro

OICR-9429 binds WDR5 with high affinity (Kd=93±28 nM) and competitively disrupts its interaction with a high-affinity Wdr5-interacting (WIN) peptide of MLL (Kdisp=64±4 nM)^[1].