 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 1831110-54-3 |
| Molecular formula(MF) | C17H25N3O |
| Molecular Weight(MW): | 287.40 |
| Alias |
| In vitro | DMSO | 57 mg/mL (198.32 mM) |
|---|---|---|
| Ethanol | 57 mg/mL (198.32 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively. | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Targets |
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| In vitro |
MS023 potently reduces cellular levels of H4R3me2a in MCF7 and HEK293 cells by inhibiting PRMT1/6 methyltransferase activity with IC50 of 9 nM and 56 nM, respectively. MS023 also inhibits cell growth and potentially induces growth arrest and flattening morphology at low concentrations. [1] |