 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 223387-75-5 |
| Molecular formula(MF) | C12H9ClN2O4 |
| Molecular Weight(MW): | 280.66 |
| Alias |
| In vitro | DMSO | 56 mg/mL (199.52 mM) |
|---|---|---|
| Water | <1 mg/mL | |
| Ethanol | <1 mg/mL | |
| In vivo |
| Description | FG-2216 is a potent, and orally active HIF prolyl 4-hydroxylase inhibitor with IC50 of 3.9 μM for PHD2. Phase 2. | ||
|---|---|---|---|
| Targets |
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| In vitro |
FG-2216 shows the ability to stabilize HIF-α to stimulate EPO secretion. [1] |
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| In vivo | In male rhesus macaques, FG-2216 (60 mg/kg, p.o.), induces significant and reversible Epo induction, and induces a small elevation of HbF expression. [2] |