 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 312917-14-9 |
| Molecular formula(MF) | C20H16N2Os |
| Molecular Weight(MW): | 332.42 |
| Alias |
| In vitro | DMSO | 20 mg/mL (60.16 mM) |
|---|---|---|
| Water | <1 mg/mL | |
| Ethanol | <1 mg/mL | |
| In vivo |
| Description | JNK inhibitor IX is a selective and potent JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively. | ||||
|---|---|---|---|---|---|
| Targets |
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| In vitro |
JNK inhibitor IX significantly reduces caspase-3 activity by the inhibition of JNK activity in human dermal fibroblasts. [2] JNK inhibition by JNK inhibitor IX significantly increases apoptotic death in response to imatinib mesylate (IM) by preventing c-ABL complete de-phosphorylation at Ser residues. [3] |