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MHY1485

(CAS No:326914-06-1)

MHY1485 is a potent, and cell-permeable mTOR activator, and also potently inhibits autophagy.

CAS No:326914-06-1

Molecular Weight(MW):387.39

Purity:99.00%

Specification:500MG;1G;5G;10G;50G;100G

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QC Documents

COA	MSDS	HPLC	NMR

ChemicalInfomation

CAS No:	326914-06-1
Molecular formula(MF)	C₁₇H₂₁N₇O₄
Molecular Weight(MW):	387.39
Alias

Solubility

In vitro	DMSO	4 mg/mL (10.32 mM)
	Water	<1 mg/mL
	Ethanol	<1 mg/mL
In vivo

Biological Activity

Description

MHY1485 is a potent, and cell-permeable mTOR activator, and also potently inhibits autophagy.

Targets

mTOR ^[1]

In vitro

MHY1485 suppresses the basal autophagic flux. MHY1485 causes the accumulation of LC3II and enlargement of the autophagosomes in a dose- and time- dependent manner.^[1] MHY1485 increases phospho-mTOR levels and phosphorylation of downstream S6K1 and rpS6 proteins without affecting total mTOR content, total S6K1 and rpS6 levels. Short-term treatment of ovaries with MHY1485 followed by allo-transplantation promoted secondary follicle growth. Treatment with MHY1485 and subsequent grafting allowed the derivation of mature oocytes and healthy offspring.^[2]