 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 361185-42-4 |
| Molecular formula(MF) | C25H20N4O3 |
| Molecular Weight(MW): | 424.45 |
| Alias |
| In vitro | DMSO | 84 mg/mL (197.9 mM) |
|---|---|---|
| Water | <1 mg/mL | |
| Ethanol | <1 mg/mL | |
| In vivo |
| Description | RBC8 is a selective inhibitor of the GTPases RalA and RalB by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases Ras and RhoA. |
|---|---|
| In vitro |
In living cells, RBC8 also reduces the activation of RalA by inducing chemical shift changes in RalB–GDP. In Ral-dependent lines H2122 and H358, RBC8 causes anchorage-independent growth inhibition with IC50 of 3.5 µM and 3.4 µM, respectively. [1] |
| In vivo | In mice bearing H358 xenografts, RBC8 (50 mg/kg i.p.) inhibits tumor growth via specific inhibition of RalA and RalB. [1] |