COA | MSDS | HPLC | NMR |
CAS No: | 423735-93-7 |
Molecular formula(MF) | C17H17BrN2O2 |
Molecular Weight(MW): | 361.23 |
Alias |
In vitro | DMSO | 72 mg/mL (199.31 mM) |
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Water | <1 mg/mL | |
Ethanol | <1 mg/mL | |
In vivo |
Description | ML-161 is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM. |
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In vitro |
ML-161 is an allosteric inhibitor of PAR1. ML-161 displays dose-dependent inhibition of thrombin-induced platelet activation, as measured by P-selectin expression. ML-161 displays selective inhibition of SFLLRN and thrombin-induced platelet aggregation, both of which operate via PAR1, and has no effect on AYPGKF, thromboxane, or ADP-induced platelet aggregation, which are all agonists at alternative platelet GPCRs. [1] |