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ML 161

(CAS No:423735-93-7)
ML-161 is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM.
CAS No:423735-93-7
Molecular Weight(MW):361.23
Purity:99.00%
Specification:500MG;1G;5G;10G;50G;100G
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QC Documents
 COA  MSDS  HPLC  NMR
ChemicalInfomation
CAS No: 423735-93-7
Molecular formula(MF) C17H17BrN2O2
Molecular Weight(MW): 361.23
Alias
Solubility
In vitro DMSO 72 mg/mL (199.31 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo
Biological Activity
Description ML-161 is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM.
In vitro

ML-161 is an allosteric inhibitor of PAR1. ML-161 displays dose-dependent inhibition of thrombin-induced platelet activation, as measured by P-selectin expression. ML-161 displays selective inhibition of SFLLRN and thrombin-induced platelet aggregation, both of which operate via PAR1, and has no effect on AYPGKF, thromboxane, or ADP-induced platelet aggregation, which are all agonists at alternative platelet GPCRs. [1]