 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 442632-72-6 |
| Molecular formula(MF) | C16H16N2Os |
| Molecular Weight(MW): | 284.38 |
| Alias |
| In vitro | DMSO | 57 mg/mL (200.43 mM) |
|---|---|---|
| Ethanol | 50 mg/mL (175.82 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively. | ||||||
|---|---|---|---|---|---|---|---|
| Targets |
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| In vitro |
CK-636 inhibits actin polymerization mediated by Arp2/3 complex in live cells, and reduces the formation of actin filament comet tails by Listeria in infected SKOV3 cells. [1] CK-636 inhibits lamellipodia formation at the leading edges of migrating T cells, and causes reduced velocity. In addition, a substantial fraction of CK-636-treated T cells on zigzag patterns with an acute turning angle are trapped near the interfaces formed by the turning points of zigzag patterns. [2] |