 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 459147-39-8 |
| Molecular formula(MF) | C21H20N2Os3 |
| Molecular Weight(MW): | 412.59 |
| Alias |
| In vitro | DMSO | 83 mg/mL (201.16 mM) |
|---|---|---|
| Ethanol | 32 mg/mL warmed (77.55 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | SW033291 is a selective inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) with IC50 and Kiapp of 1.5 nM and 0.1 nM, respectively. | ||||
|---|---|---|---|---|---|
| Targets |
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| In vitro |
In Vaco-503 cells, SW033291 (2.5 μM) decreases cellular 15-PGDH enzyme activity by 85%.[1] |
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| In vivo | In mice receiving a bone marrow transplant, SW033291 (10 mg/kg, i.p.) promotes hematopoietic recovery. In mouse models of colon and liver injury, SW033291 (10 mg/kg, i.p.) reduces the levels of colitis-associated inflammatory cytokines, protects mice from colitis, and promotes liver regeneration. [1] |