COS1 cells |
Function assay |
|
|
|
Agonist activity at FXR expressed in COS1 cells by cell-based bioluminescence assay, EC50=99 nM |
20014870 |
HeLa cells |
Function assay |
|
24 h |
|
Agonist activity at human full length FXR expressed in HeLa cells cotransfected with pSG5-human RXR after 24 hrs by Dual-Glo luciferase reporter gene assay, EC50=0.16 μM |
25934227 |
CHO cells |
Function assay |
|
5 h |
|
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay, EC50=0.755 μM |
17685603 |
NCI-H716 cells |
Function assay |
|
|
|
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay, EC50=20 μM |
21459580 |
mouse GLUTag cells |
Function assay |
|
|
|
Agonist activity at GP-BAR1 in mouse GLUTag cells assessed as increase in intracellular cAMP level |
24387325 |
human HepG2 cells |
Function assay |
10 μM |
18 h |
|
Agonist activity at FXR in human HepG2 cells assessed as upregulation of SHP mRNA expression at 10 uM after 18 hrs by RT-PCR analysis |
24387325 |
mouse primary hepatocytes |
Function assay |
|
|
|
Agonist activity at FXR in mouse primary hepatocytes assessed as upregulation of BESP mRNA expression |
24387325 |