 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 4727-31-5 |
| Molecular formula(MF) | C20H15NO3 |
| Molecular Weight(MW): | 317.34 |
| Alias |
| In vitro | DMSO | 63 mg/mL (198.52 mM) |
|---|---|---|
| Ethanol | 18 mg/mL warmed (56.72 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes. | ||
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| Targets |
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| In vitro |
Kartogenin induces chondrocyte differentiation from hMSCs by enhancing the nuclear localization of CBFβ, and protects articular chondrocytes. [1] Kartogenin promotes the type-I collagen synthesis of dermal fibroblasts via activation of the smad4/smad5 pathway without obvious cytotoxicity on fibroblasts’ viability, morphology and survival. [2] |
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| In vivo | Kartogenin promotes cartilage repair in collagenase VII (10 μM)– and surgery (100 μM)-induced OA models in mice. [1] Kartogenin (100 nM) also stimulats collagen synthesis in the mouse dermis. [2] In addition, Kartogenin stimulates mouse limb skeletal growth and synovial joint development. [3] |