Home > Products > Others > 1,?5-?Dihydro-?3-?hydroxy-?4-?[3-?methyl-?4-?(phenylmethoxy)?benzoyl]?-?1-?[3-?(4-?morpholinyl)?propyl]?-?5-?(4-?pyridinyl)?-?2H-?pyrrol-?2-?one

1,?5-?Dihydro-?3-?hydroxy-?4-?[3-?methyl-?4-?(phenylmethoxy)?benzoyl]?-?1-?[3-?(4-?morpholinyl)?propyl]?-?5-?(4-?pyridinyl)?-?2H-?pyrrol-?2-?one

(CAS No:489415-96-5)

SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.

CAS No:489415-96-5

Molecular Weight(MW):527.61

Purity:98%

Specification:500mg;1g;5g;10g;50g;100g

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QC Documents

COA	MSDS	HPLC	NMR

ChemicalInfomation

CAS No:	489415-96-5
Molecular formula(MF)	C₃₁H₃₃N₃O₅
Molecular Weight(MW):	527.61
Alias

Solubility

In vitro	DMSO	100 mg/mL (189.53 mM)
	Water	<1 mg/mL
	Ethanol	<1 mg/mL
In vivo	5% DMSO+45% PEG 300+ddH2O	7mg/mL

Biological Activity

Description

SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.

Targets

PCSK9 ^[1]

In vitro

In HepG2 cells, SBC-115076 increases the uptake of Fluorescent Dil-LDL. ^[1]

In vivo

In mice that are fed high fat diet, SBC-115076 (8 mg/kg) lowers cholesterol levels by 32%. ^[1]