 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 521937-07-5 |
| Molecular formula(MF) | C12H11NO3 |
| Molecular Weight(MW): | 219.24 |
| Alias |
| In vitro | DMSO | 43 mg/mL (196.13 mM) |
|---|---|---|
| Water | <1 mg/mL | |
| Ethanol | <1 mg/mL | |
| In vivo |
| Description | CID755673 is a cell-active pan-PKD1/2/3 inhibitor with IC50 of 180 nM, 280nM, and 227 nM, respectively, about 200-fold selectivity over other CAMKs. | ||||||
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| Targets |
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| In vitro |
In LNCaP prostate cancer cells, CID755673 directly inhibits PKD1 activity. In HeLa cells, CID755673 significantly blocks PMA-induced nuclear export of HDAC5, and blocks PKD-mediated protein transport. In prostate cancer cells, CID755673 potently blocks cell migration and invasion, and also shows inhibition activity on tumor cell proliferation and cell cycle distribution. [1] In addition, CID755673 alter primary human NK cell effector functions. [3] |
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| In vivo | CID755673, via PKD/PKD1 inhibition, significantly ameliorates necrosis and severity of pancreatitis in a rat acute pancreatitis model. [2] |