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N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

(CAS No:55778-02-4)

WZ811 is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM.

CAS No:55778-02-4

Molecular Weight(MW):290.36

Purity:98%+

Specification:500mg;1g;5g;10g;50g;100g

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QC Documents

COA	MSDS	HPLC	NMR

ChemicalInfomation

CAS No:	55778-02-4
Molecular formula(MF)	C₁₈H₁₈N₄
Molecular Weight(MW):	290.36
Alias

Solubility

In vitro	DMSO	30 mg/mL (103.32 mM)
	Water	<1 mg/mL
	Ethanol	<1 mg/mL

Biological Activity

Description

WZ811 is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM.

Targets

CXCR4 ^[1]

0.3 nM(EC50)

In vitro

WZ811 is a highly potent competitive antagonist of CXCR4. WZ811 is effective in counteracting SDF-1 on cAMP reduction at doses as low as a few nanomoles. WZ811 blocks SDF-1-mediated invasion with EC50 of 5.2 nM. ^[1]