 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 62717-42-4 |
| Molecular formula(MF) | C16H17NO2.HCl |
| Molecular Weight(MW): | 291.77 |
| Alias |
| In vitro | DMSO | 58 mg/mL (198.78 mM) |
|---|---|---|
| Ethanol | 6 mg/mL warmed (20.56 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | SKF38393 HCl is a selective dopamine D1/D5 receptor agonist. | ||
|---|---|---|---|
| Targets |
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| In vitro |
SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. [1] In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. [2] In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations. [4] |
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| In vivo | SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. [3] In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning. [5] |