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Olaparib

(CAS No:763113-22-0)

Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1.

CAS No:763113-22-0

Molecular Weight(MW):434.46

Purity:98%+

Specification:500mg;1g;5g;10g;50g;100g

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QC Documents

COA	MSDS	HPLC	NMR

ChemicalInfomation

CAS No:	763113-22-0
Molecular formula(MF)	C₂₄H₂₃FN₄O₃
Molecular Weight(MW):	434.46
Alias	1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine

Solubility

In vitro	DMSO	86 mg/mL warmed (197.94 mM)
	Water	0.002 mg/mL (0.0 mM)
	Ethanol	<1 mg/mL
In vivo	4% DMSO+30% PEG 300+ddH2O	5mg/mL

Biological Activity

Description

Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1.

Features

A potent PARP inhibitor (currently in late stage clinical trials).

Targets

PARP2 ^[1] (Cell-free assay)	PARP1 ^[1] (Cell-free assay)	Tankyrase-1 ^[1] (Cell-free assay)
1 nM	5 nM	1.5 μM

In vitro

Olaparib would act against BRCA1 or BRCA2 mutations. Olaparib is not sensitive to tankyrase-1 (IC50 >1 μM). Olaparib could ablate the PARP-1 activity at concentrations of 30-100 nM in SW620 cells. Olaparib is hypersensitive to BRCA1-deficient cell lines (MDA-MB-463 and HCC1937), compared with BRCA1- and BRCA2-proficient cell lines (Hs578T, MDA-MB-231, and T47D). ^[1] Olaparib is strongly sensitive to KB2P cells due to suppression of base excision repair by PARP inhibition, which may result in the conversion of single-strand breaks to double-strand breaks during DNA replication, thus activating BRCA2-dependent recombination pathways. ^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
KP3.33	Growth Inhibition Assay		4 d		IC50=5.705 Î¼M	18559613
KP6.3	Growth Inhibition Assay		4 d		IC50=10.428 Î¼M	18559613
KP7.7	Growth Inhibition Assay		4 d		IC50=57 nM	18559613
KB2P3.4	Growth Inhibition Assay		4 d		IC50=124 M	18559613
KB2P1.21	Growth Inhibition Assay		4 d		IC50=8907 nM	18559613
U373-MG	Cytotoxic Assay	1 Î¼M	24 h		Increases radiation sensitivity	18954712
T98G	Cytotoxic Assay	1 Î¼M	24 h		Increases radiation sensitivity	18954712
U87-MG	Cytotoxic Assay	1 Î¼M	24 h		Increases radiation sensitivity	18954712
UVW	Cytotoxic Assay	500 nM	24 h		Increases radiation sensitivity	18954712
HeLa	Function Assay	500 nM	4 h		Causes a modest delay in rejoining of radiation-induced DNA breaks	18954712
HeLa	Function Assay	1 Î¼M	24 h		Enhances radiation-induced S-phase arrest	18954712
T98G	Function Assay	1 Î¼M	24 h		Enhances radiation-induced S-phase arrest	18954712
L3	Cytotoxic Assay	5 Î¼M	96 h	DMSO	Significantly inhibits cell survival	20124459
Granta-519	Cytotoxic Assay	5 Î¼M	96 h	DMSO	Slightly inhibits cell survival	20124459
BT	Cytotoxic Assay	5 Î¼M	96 h	DMSO	Slightly inhibits cell survival	20124459
UPN2	Cytotoxic Assay	5 Î¼M	96 h	DMSO	Slightly inhibits cell survival	20124459
HBL-2	Cytotoxic Assay	5 Î¼M	96 h	DMSO	Slightly inhibits cell survival	20124459
JVM-2	Cytotoxic Assay	5 Î¼M	96 h	DMSO	Slightly inhibits cell survival	20124459
Z138	Cytotoxic Assay	5 Î¼M	96 h	DMSO	Slightly inhibits cell survival	20124459
RWPE	Invasive Assay	25 Î¼M	48 h	DMSO	Significantly reduces ERG-driven cell invasion	21575865
VCaP	Invasive Assay	25 Î¼M	48 h	DMSO	Significantly reduces ERG-driven cell invasion	21575865
Mouse H2AX−/− ES Cells	Cytotoxic Assay	2.5 Î¼M	20 h		Significantly inhibits cell survival	23355489
Mouse ATM−/− ES Cells	Cytotoxic Assay	2.5 Î¼M	20 h		Significantly inhibits cell survival	23355489
H1650	Growth Inhibition Assay	20 Î¼M	144 h		IC50=15.47 Î¼M	23239809
H1650PTEN+	Growth Inhibition Assay	20 Î¼M	144 h		IC50=50.83 Î¼M	23239809
PC-9	Growth Inhibition Assay	20 Î¼M	144 h		IC50=5.88 Î¼M	23239809
PC-9PTEN−	Growth Inhibition Assay	20 Î¼M	144 h		IC50=6.52 Î¼M	23239809
MDA-MB-231	Growth Inhibition Assay		5 day		IC50=6.9 Î¼M	23760496
MDA-MB-468	Growth Inhibition Assay		5 day		IC50=5.0 Î¼M	23760496
BT20	Growth Inhibition Assay		5 day		IC50=7.7 Î¼M	23760496
HCC1143	Growth Inhibition Assay		5 day		IC50=11.1 Î¼M	23760496
HCC1937	Growth Inhibition Assay		5 day		IC50=12.6 Î¼M	23760496
Hs578t	Growth Inhibition Assay		5 day		IC50=5.6 Î¼M	23760496
Hs578t(si)	Growth Inhibition Assay		5 day		IC50=7.5 Î¼M	23760496
BT474	Growth Inhibition Assay		5 day		IC50=19.8 Î¼M	23760496
JIMT1	Growth Inhibition Assay		5 day		IC50=7.7 Î¼M	23760496
SKBR3	Growth Inhibition Assay		5 day		IC50=11.1 Î¼M	23760496
SUM159	Growth Inhibition Assay		5 day		IC50=4.2 Î¼M	23760496
CAMA1	Growth Inhibition Assay		5 day		IC50=15.8 Î¼M	23760496
MCF7	Growth Inhibition Assay		5 day		IC50=5.8 Î¼M	23760496
T47D	Growth Inhibition Assay		5 day		IC50=9.6 Î¼M	23760496
HCT116	Growth Inhibition Assay	100 Î¼M	48 h	DMSO	IC50=2.5 Î¼M	24577941
SW1116	Growth Inhibition Assay	100 Î¼M	48 h	DMSO	IC50=100 Î¼M	24577941
HT29	Growth Inhibition Assay	100 Î¼M	48 h	DMSO	IC50=14.7 Î¼M	24577941
LoVo	Growth Inhibition Assay	100 Î¼M	48 h	DMSO	IC50=13.4 Î¼M	24577941
HCT-15	Growth Inhibition Assay	100 Î¼M	48 h	DMSO	IC50=10 Î¼M	24577941
SW48	Growth Inhibition Assay	100 Î¼M	48 h	DMSO	IC50=9.5 Î¼M	24577941
C-1	Growth Inhibition Assay	100 Î¼M	48 h	DMSO	IC50=7.6 Î¼M	24577941
RKO	Growth Inhibition Assay	100 Î¼M	48 h	DMSO	IC50=5.9 Î¼M	24577941
HCT116	Growth Inhibition Assay	100 Î¼M	48 h	DMSO	Potentiates SN-38 cytotoxicity	24577941
SW1116	Growth Inhibition Assay	100 Î¼M	48 h	DMSO	Potentiates SN-38 cytotoxicity	24577941
HT29	Growth Inhibition Assay	100 Î¼M	48 h	DMSO	Potentiates SN-38 cytotoxicity	24577941
LoVo	Growth Inhibition Assay	100 Î¼M	48 h	DMSO	Potentiates SN-38 cytotoxicity	24577941
SW48	Growth Inhibition Assay	100 Î¼M	48 h	DMSO	Potentiates SN-38 cytotoxicity	24577941
C-1	Growth Inhibition Assay	100 Î¼M	48 h	DMSO	Potentiates SN-38 cytotoxicity	24577941
RKO	Growth Inhibition Assay	100 Î¼M	48 h	DMSO	Potentiates SN-38 cytotoxicity	24577941
HCT116	Function Assay	10 nM	12 h	DMSO	Increases DNA double-strand breaks induced by SN-38	24577941
HT29	Function Assay	10 nM	12 h	DMSO	Increases DNA double-strand breaks induced by SN-38	24577941
TE-6	Function Assay	5 Î¼M	12 h	DMSO	Induces G2/M arrest	24219164
TE-6	Function Assay	5 Î¼M	24 h	DMSO	Increases in double strand breaks (DSBs)	24219164
Hep3B	Growth Inhibition Assay	40 Î¼M	72 h	DMSO	Synergistically inhibits cell growth with DHMEQ	25072752
Huh7	Growth Inhibition Assay	40 Î¼M	72 h	DMSO	Synergistically inhibits cell growth with DHMEQ	25072752
Hep3B	Function Assay	40 Î¼M	24 h	DMSO	Induces ROS production with DHMEQ	25072752
Huh7	Function Assay	40 Î¼M	24 h	DMSO	Induces ROS production with DHMEQ	25072752
Hep3B	Function Assay	40 Î¼M	24 h	DMSO	Induces cell autophagy with DHMEQ	25072752
Huh7	Function Assay	40 Î¼M	24 h	DMSO	Induces cell autophagy with DHMEQ	25072752
SGC-7901	Growth Inhibition Assay	30Â Î¼M	48 h	DMSO	Block oxaliplatin-induced cell death	25767076
COLO-800	Growth Inhibition Assay				IC50=0.44164 Î¼M	SANGER
EoL-1-	Growth Inhibition Assay				IC50=0.56446 Î¼M	SANGER
NCI-H209	Growth Inhibition Assay				IC50=0.91556 Î¼M	SANGER
ES1	Growth Inhibition Assay				IC50=1.11408 Î¼M	SANGER
NKM-1	Growth Inhibition Assay				IC50=1.25347 Î¼M	SANGER
NTERA-S-cl-D1	Growth Inhibition Assay				IC50=1.33341 Î¼M	SANGER
MHH-ES-1	Growth Inhibition Assay				IC50=1.62067 Î¼M	SANGER
ES8	Growth Inhibition Assay				IC50=1.72414 Î¼M	SANGER
NCI-H720	Growth Inhibition Assay				IC50=2.20699 Î¼M	SANGER
EW-3	Growth Inhibition Assay				IC50=2.27534 Î¼M	SANGER
D-566MG	Growth Inhibition Assay				IC50=2.44568 Î¼M	SANGER
697	Growth Inhibition Assay				IC50=2.84173 Î¼M	SANGER
ES5	Growth Inhibition Assay				IC50=2.88189 Î¼M	SANGER
COLO-684	Growth Inhibition Assay				IC50=3.51696 Î¼M	SANGER
ML-2	Growth Inhibition Assay				IC50=3.60058 Î¼M	SANGER
MC-IXC	Growth Inhibition Assay				IC50=3.63393 Î¼M	SANGER
DB	Growth Inhibition Assay				IC50=3.65448 Î¼M	SANGER
HCC2218	Growth Inhibition Assay				IC50=3.73103 Î¼M	SANGER
NCI-H510A	Growth Inhibition Assay				IC50=3.82724 Î¼M	SANGER
NCI-H526	Growth Inhibition Assay				IC50=3.86958 Î¼M	SANGER
MV-4-11	Growth Inhibition Assay				IC50=4.13334 Î¼M	SANGER
PA-1	Growth Inhibition Assay				IC50=4.2529 Î¼M	SANGER
EW-22	Growth Inhibition Assay				IC50=4.3586 Î¼M	SANGER
KASUMI-1	Growth Inhibition Assay				IC50=4.40109 Î¼M	SANGER
LU-139	Growth Inhibition Assay				IC50=4.75829 Î¼M	SANGER
SBC-1	Growth Inhibition Assay				IC50=4.80908 Î¼M	SANGER
H4	Growth Inhibition Assay				IC50=4.89443 Î¼M	SANGER
EW-11	Growth Inhibition Assay				IC50=5.08072 Î¼M	SANGER
NBsusSR	Growth Inhibition Assay				IC50=5.12055 Î¼M	SANGER
RPMI-8226	Growth Inhibition Assay				IC50=5.15244 Î¼M	SANGER
DEL	Growth Inhibition Assay				IC50=5.20006 Î¼M	SANGER
ES4	Growth Inhibition Assay				IC50=5.51389 Î¼M	SANGER
GCT	Growth Inhibition Assay				IC50=5.56856 Î¼M	SANGER
NCI-H1048	Growth Inhibition Assay				IC50=5.97273 Î¼M	SANGER
NCI-SNU-1	Growth Inhibition Assay				IC50=6.022 Î¼M	SANGER
ES7	Growth Inhibition Assay				IC50=6.03577 Î¼M	SANGER
SW982	Growth Inhibition Assay				IC50=6.09137 Î¼M	SANGER
L-363	Growth Inhibition Assay				IC50=6.33974 Î¼M	SANGER
HT-1080	Growth Inhibition Assay				IC50=6.49683 Î¼M	SANGER
HAL-01	Growth Inhibition Assay				IC50=6.5109 Î¼M	SANGER
NB14	Growth Inhibition Assay				IC50=6.64039 Î¼M	SANGER
EW-13	Growth Inhibition Assay				IC50=6.77424 Î¼M	SANGER
NY	Growth Inhibition Assay				IC50=6.94605 Î¼M	SANGER
NCI-SNU-5	Growth Inhibition Assay				IC50=7.10433 Î¼M	SANGER
MS-1	Growth Inhibition Assay				IC50=7.17494 Î¼M	SANGER
EW-16	Growth Inhibition Assay				IC50=7.31861 Î¼M	SANGER
LU-65	Growth Inhibition Assay				IC50=7.48417 Î¼M	SANGER
HGC-27	Growth Inhibition Assay				IC50=7.72173 Î¼M	SANGER
CTB-1	Growth Inhibition Assay				IC50=7.76175 Î¼M	SANGER
5637	Growth Inhibition Assay				IC50=7.9286 Î¼M	SANGER
U251	Growth Inhibition Assay				IC50=7.94016 Î¼M	SANGER
HOS	Growth Inhibition Assay				IC50=8.23007 Î¼M	SANGER
DOHH-2	Growth Inhibition Assay				IC50=8.2358 Î¼M	SANGER
EW-1	Growth Inhibition Assay				IC50=8.30088 Î¼M	SANGER
BV-173	Growth Inhibition Assay				IC50=8.5554 Î¼M	SANGER
8-MG-BA	Growth Inhibition Assay				IC50=8.68988 Î¼M	SANGER
NB69	Growth Inhibition Assay				IC50=8.70921 Î¼M	SANGER
NCI-H69	Growth Inhibition Assay				IC50=9.90961 Î¼M	SANGER
RS4-11	Growth Inhibition Assay				IC50=11.2208 Î¼M	SANGER
ONS-76	Growth Inhibition Assay				IC50=11.2947 Î¼M	SANGER
SF539	Growth Inhibition Assay				IC50=11.4889 Î¼M	SANGER
HuO-3N1	Growth Inhibition Assay				IC50=11.5796 Î¼M	SANGER
NCI-H1651	Growth Inhibition Assay				IC50=12.3115 Î¼M	SANGER
KARPAS-45	Growth Inhibition Assay				IC50=12.376 Î¼M	SANGER
SK-NEP-1	Growth Inhibition Assay				IC50=12.4609 Î¼M	SANGER
LAMA-84	Growth Inhibition Assay				IC50=13.1095 Î¼M	SANGER
NCI-H1155	Growth Inhibition Assay				IC50=13.2856 Î¼M	SANGER
CTV-1	Growth Inhibition Assay				IC50=13.445 Î¼M	SANGER
QIMR-WIL	Growth Inhibition Assay				IC50=13.7814 Î¼M	SANGER
H9	Growth Inhibition Assay				IC50=13.8475 Î¼M	SANGER
SK-MEL-1	Growth Inhibition Assay				IC50=13.9347 Î¼M	SANGER
HD-MY-Z	Growth Inhibition Assay				IC50=14.0637 Î¼M	SANGER
TI-73	Growth Inhibition Assay				IC50=14.2356 Î¼M	SANGER
JVM-3	Growth Inhibition Assay				IC50=15.5716 Î¼M	SANGER
D-247MG	Growth Inhibition Assay				IC50=15.593 Î¼M	SANGER
VA-ES-BJ	Growth Inhibition Assay				IC50=15.6097 Î¼M	SANGER
NOS-1	Growth Inhibition Assay				IC50=15.6522 Î¼M	SANGER
MOLT-4	Growth Inhibition Assay				IC50=16.752 Î¼M	SANGER
Mo-T	Growth Inhibition Assay				IC50=17.0849 Î¼M	SANGER
NCI-H1770	Growth Inhibition Assay				IC50=17.1543 Î¼M	SANGER
COLO-320-HSR	Growth Inhibition Assay				IC50=17.1827 Î¼M	SANGER
TE-12	Growth Inhibition Assay				IC50=17.7054 Î¼M	SANGER
NCI-H82	Growth Inhibition Assay				IC50=17.8728 Î¼M	SANGER
NEC8	Growth Inhibition Assay				IC50=18.1316 Î¼M	SANGER
HSC-3	Growth Inhibition Assay				IC50=18.7414 Î¼M	SANGER
NCI-H1092	Growth Inhibition Assay				IC50=18.7595 Î¼M	SANGER
NCI-H292	Growth Inhibition Assay				IC50=19.0489 Î¼M	SANGER
L-428	Growth Inhibition Assay				IC50=19.559 Î¼M	SANGER
LU-134-A	Growth Inhibition Assay				IC50=19.572 Î¼M	SANGER
GI-ME-N	Growth Inhibition Assay				IC50=19.5747 Î¼M	SANGER
ALL-PO	Growth Inhibition Assay				IC50=19.5972 Î¼M	SANGER
D-283MED	Growth Inhibition Assay				IC50=19.915 Î¼M	SANGER
D-423MG	Growth Inhibition Assay				IC50=19.9967 Î¼M	SANGER
CAKI-1	Growth Inhibition Assay				IC50=20.2219 Î¼M	SANGER
ETK-1	Growth Inhibition Assay				IC50=20.2615 Î¼M	SANGER
G-402	Growth Inhibition Assay				IC50=20.5334 Î¼M	SANGER
HL-60	Growth Inhibition Assay				IC50=21.1613 Î¼M	SANGER
A2058	Growth Inhibition Assay				IC50=21.4477 Î¼M	SANGER
CHP-212	Growth Inhibition Assay				IC50=21.9051 Î¼M	SANGER
KY821	Growth Inhibition Assay				IC50=21.975 Î¼M	SANGER
TYK-nu	Growth Inhibition Assay				IC50=22.0651 Î¼M	SANGER
JVM-2	Growth Inhibition Assay				IC50=22.2983 Î¼M	SANGER
KU812	Growth Inhibition Assay				IC50=22.7312 Î¼M	SANGER
MKN28	Growth Inhibition Assay				IC50=22.9015 Î¼M	SANGER
ECC10	Growth Inhibition Assay				IC50=23.741 Î¼M	SANGER
BHT-101	Growth Inhibition Assay				IC50=24.0008 Î¼M	SANGER
DU-4475	Growth Inhibition Assay				IC50=24.3337 Î¼M	SANGER
769-P	Growth Inhibition Assay				IC50=24.8466 Î¼M	SANGER
HEC-1	Growth Inhibition Assay				IC50=25.445 Î¼M	SANGER
MOLT-13	Growth Inhibition Assay				IC50=25.5331 Î¼M	SANGER
8505C	Growth Inhibition Assay				IC50=26.4977 Î¼M	SANGER
GB-1	Growth Inhibition Assay				IC50=26.7176 Î¼M	SANGER
SF126	Growth Inhibition Assay				IC50=26.7648 Î¼M	SANGER
A4-Fuk	Growth Inhibition Assay				IC50=27.1271 Î¼M	SANGER
OVCAR-8	Growth Inhibition Assay				IC50=27.1539 Î¼M	SANGER
NCI-H1304	Growth Inhibition Assay				IC50=27.54 Î¼M	SANGER
GR-ST	Growth Inhibition Assay				IC50=28.047 Î¼M	SANGER
G-401	Growth Inhibition Assay				IC50=28.5096 Î¼M	SANGER
LXF-289	Growth Inhibition Assay				IC50=28.5651 Î¼M	SANGER
DBTRG-05MG	Growth Inhibition Assay				IC50=28.9204 Î¼M	SANGER
YKG-1	Growth Inhibition Assay				IC50=29.868 Î¼M	SANGER
GAMG	Growth Inhibition Assay				IC50=29.993 Î¼M	SANGER
HCT-116	Growth Inhibition Assay				IC50=30.0548 Î¼M	SANGER
S-117	Growth Inhibition Assay				IC50=31.2257 Î¼M	SANGER
NCI-H1693	Growth Inhibition Assay				IC50=33.6542 Î¼M	SANGER
A427	Growth Inhibition Assay				IC50=33.9976 Î¼M	SANGER
HT-29	Growth Inhibition Assay				IC50=34.6032 Î¼M	SANGER
P12-ICHIKAWA	Growth Inhibition Assay				IC50=34.7491 Î¼M	SANGER
CAL-51	Growth Inhibition Assay				IC50=35.0709 Î¼M	SANGER
Ramos-2G6-4C10	Growth Inhibition Assay				IC50=35.2425 Î¼M	SANGER
SCH	Growth Inhibition Assay				IC50=36.4174 Î¼M	SANGER
SK-MEL-24	Growth Inhibition Assay				IC50=36.9044 Î¼M	SANGER
SW1573	Growth Inhibition Assay				IC50=38.7216 Î¼M	SANGER
BALL-1	Growth Inhibition Assay				IC50=39.2129 Î¼M	SANGER
BE-13	Growth Inhibition Assay				IC50=39.329 Î¼M	SANGER
GI-1	Growth Inhibition Assay				IC50=39.8647 Î¼M	SANGER
GOTO	Growth Inhibition Assay				IC50=39.9139 Î¼M	SANGER
A673	Growth Inhibition Assay				IC50=41.0343 Î¼M	SANGER
KG-1	Growth Inhibition Assay				IC50=43.394 Î¼M	SANGER
GP5d	Growth Inhibition Assay				IC50=44.0666 Î¼M	SANGER
MFM-223	Growth Inhibition Assay				IC50=44.1228 Î¼M	SANGER
OAW-42	Growth Inhibition Assay				IC50=44.2643 Î¼M	SANGER
C8166	Growth Inhibition Assay				IC50=45.0822 Î¼M	SANGER
LU-99A	Growth Inhibition Assay				IC50=46.1322 Î¼M	SANGER
NCI-H23	Growth Inhibition Assay				IC50=46.1785 Î¼M	SANGER
HO-1-N-1	Growth Inhibition Assay				IC50=47.0998 Î¼M	SANGER
A3-KAW	Growth Inhibition Assay				IC50=47.1007 Î¼M	SANGER
CGTH-W-1	Growth Inhibition Assay				IC50=47.5069 Î¼M	SANGER
DJM-1	Growth Inhibition Assay				IC50=47.5413 Î¼M	SANGER
A101D	Growth Inhibition Assay				IC50=47.6357 Î¼M	SANGER
BB30-HNC	Growth Inhibition Assay				IC50=48.3072 Î¼M	SANGER
T98G	Growth Inhibition Assay				IC50=48.4633 Î¼M	SANGER
NCI-H1573	Growth Inhibition Assay				IC50=49.4462 Î¼M	SANGER
MEG-01	Growth Inhibition Assay				IC50=49.7411 Î¼M	SANGER
WM-115	Growth Inhibition Assay				IC50=49.9222 Î¼M	SANGER

... Click to View More Cell Line Experimental Data

In vivo

Combining with temozolomide, Olaparib (10 mg/kg, p.o.) significantly suppresses tumor growth in SW620 xenografts. ^[1] Olaparib shows great response to Brca1^-/-;p53^-/- mammary tumors (50 mg/kg i.p. per day), while no responses to HR-deficient Ecad^-/-;p53^-/- mammary tumors. Olaparib even does not show dose-limiting toxicity in tumor-bearing mice. ^[3] Olaparib has been used to treat with BRCA mutated tumors, such as ovarian, breast and prostate cancers. Moreover, Olaparib shows selectively inhibition to ATM (Ataxia Telangiectasia Mutated)-deficient tumor cells, which indicates to be a potential agent for treating ATM mutant lymphoid tumors. ^[4]