 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 808118-40-3 |
| Molecular formula(MF) | C19H16N2O5 |
| Molecular Weight(MW): | 352.34 |
| Alias |
| In vitro | DMSO | 70 mg/mL (198.67 mM) |
|---|---|---|
| Water | <1 mg/mL | |
| Ethanol | <1 mg/mL | |
| In vivo | 5% DMSO+50% PEG 300+ddH2O | 11mg/mL |
| Description | Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Phase 3. | |
|---|---|---|
| Targets |
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| In vitro |
FG-4592 is an oral inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase currently in clinical development for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including erythropoietin and enzymes involved in iron metabolism. [1] |