H157 |
Growth Inhibition Assay |
0-100 μM |
72 h |
|
IC50=9 μM |
26390342 |
H2170 |
Growth Inhibition Assay |
0-100 μM |
72 h |
|
IC50=5 μM |
26390342 |
H520 |
Growth Inhibition Assay |
0-100 μM |
72 h |
|
IC50=0.73 μM |
26390342 |
H596 |
Growth Inhibition Assay |
0-100 μM |
72 h |
|
IC50=12 μM |
26390342 |
IMR-32 |
Growth Inhibition Assay |
|
48Â h |
DMSO |
IC50=261 nM |
26225123 |
SH-SY5Y |
Growth Inhibition Assay |
|
48Â h |
DMSO |
IC50=676 nM |
26225123 |
NGP |
Growth Inhibition Assay |
|
48Â h |
DMSO |
IC50=2.077 μM |
26225123 |
SH-EP |
Growth Inhibition Assay |
|
48Â h |
DMSO |
IC50=2.211 μM |
26225123 |
IMR-32 |
Growth Inhibition Assay |
1 μM |
24 h |
DMSO |
induces G1 arrest |
26225123 |
SH-SY5Y |
Growth Inhibition Assay |
1 μM |
24 h |
DMSO |
induces G1 arrest |
26225123 |
NGP |
Growth Inhibition Assay |
1 μM |
24 h |
DMSO |
induces G1 arrest |
26225123 |
SH-EP |
Growth Inhibition Assay |
1 μM |
24 h |
DMSO |
induces G1 arrest |
26225123 |
NGP |
Fuction Assay |
0-1 μM |
24 h |
DMSO |
reduces the expression of TOP2A, CCNE2, and TK1 in a dose-dependent manner |
26225123 |
IMR-32 |
Fuction Assay |
0-1 μM |
24 h |
DMSO |
reduces the expression of TOP2A, CCNE2, and TK1 in a dose-dependent manner |
26225123 |
U-CH2 |
Growth Inhibition Assay |
0-1 μM |
72 h |
|
IC50=50.2 nM |
26183925 |
U-CH3 |
Growth Inhibition Assay |
0-1 μM |
72 h |
|
IC50=52 nM |
26183925 |
U-CH6 |
Growth Inhibition Assay |
0-1 μM |
72 h |
|
IC50=90 nM |
26183925 |
U-CH7 |
Growth Inhibition Assay |
0-1 μM |
72 h |
|
IC50=98 nM |
26183925 |
U-CH11 |
Growth Inhibition Assay |
0-1 μM |
72 h |
|
IC50=340 nM |
26183925 |
MCF7 |
Fuction Assay |
2.5-250 nM |
24 h |
|
reduces Rb phosphorylation |
25991817 |
MV4-11 |
Apoptosis Assay |
0.5 μM |
24 h |
|
enhances apoptosis induced by sorafenib and AC220 |
25487917 |
MOLM13 |
Apoptosis Assay |
0.5 μM |
24 h |
|
enhances apoptosis induced by sorafenib and AC220 |
25487917 |
MOLM13-ITD alone |
Growth Inhibition Assay |
|
|
|
IC50=0.089 ± 0.009 μM |
25487917 |
MV4-11-ITD alone |
Growth Inhibition Assay |
|
|
|
IC50=0.092 ± 0.008 μM |
25487917 |
MOLM13-ITD/D835Y |
Growth Inhibition Assay |
|
|
|
IC50=0.114 ± 0.011 μM |
25487917 |
MV4-11-ITD/D835V |
Growth Inhibition Assay |
|
|
|
IC50=0.116 ± 0.011 μM |
25487917 |
MV4-11-ITD/D835V |
Growth Inhibition Assay |
|
|
|
IC50=0.102 ± 0.006 μM |
25487917 |
MV4-11-ITD/F691L |
Growth Inhibition Assay |
|
|
|
IC50=0.112 ± 0.015 μM |
25487917 |
MV4-11-ITD/N841K |
Growth Inhibition Assay |
|
|
|
IC50=0.113 ± 0.002 μM |
25487917 |
U937-FLT3 WT |
Growth Inhibition Assay |
|
|
|
IC50=0.102 ± 0.013 μM |
25487917 |