 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 832115-62-5 |
| Molecular formula(MF) | C11H10N2O2S |
| Molecular Weight(MW): | 234.27 |
| Alias |
| In vitro | DMSO | 46 mg/mL (196.35 mM) |
|---|---|---|
| Ethanol | 13 mg/mL warmed (55.49 mM) | |
| Water | <1 mg/mL | |
| In vivo | 5% DMSO+55% PEG 300+ddH2O | 10mg/mL |
| Description | Isoxazole 9 (Isx-9) is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs). |
|---|---|
| In vitro |
In NSPCs, isoxazole 9 increases cell number, and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In outgrowth EPCs, isoxazole 9 decreases tube formation without effect on early EPCs. [1] |
| In vivo | In mice, isoxazole 9 (20 mg/kg, i.p.) crosses the BBB and increases proliferation of neuroblasts and neurogenesis via Mef2-specific mechanisms in the hippocampal SGZ. Isoxazole 9 (20 mg/kg, i.p.) also increases differentiation and dendritic complexity of immature neurons and improves memory. In MWM, isoxazole 9 improves spatial memory. [2] |