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Pluripotin

(CAS No:839707-37-8)

Pluripotin (SC1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal.

CAS No:839707-37-8

Molecular Weight(MW):550.53

Purity:99.00%

Specification:500MG;1G;5G;10G;50G;100G

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QC Documents

COA	MSDS	HPLC	NMR

ChemicalInfomation

CAS No:	839707-37-8
Molecular formula(MF)	C₂₇H₂₅F₃N₈O₂
Molecular Weight(MW):	550.53
Alias

Solubility

In vitro	DMSO	100 mg/mL (181.64 mM)
	Water	<1 mg/mL
	Ethanol	<1 mg/mL
In vivo

Biological Activity

Description

Pluripotin (SC1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal.

Targets

ERK1 ^[1]	RasGAP ^[1]
98 nM(Kd)	212 nM(Kd)

In vitro

SC1 is a dual function small molecule inhibitor of both ERK1 and RasGAP and that simultaneous inhibition of both protein activities is required and sufficient for SC1’s effects on mES cells. SC1 activates Ras by inhibition of RasGAP function^[1]. SC1 improved the derivation efficiency and pluripotency of ES cells from C57BL/6. Three types of pluripotent stem cells (fES, ntES, and iPS cells) of the C57BL/6 background could generate full-term pups with high efficiency when cultured with SC1^[1].