 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 890842-28-1 |
| Molecular formula(MF) | C25H22N2O2 |
| Molecular Weight(MW): | 382.45 |
| Alias | GSK 650394; GSK-650394; SureCN3767908; CHEMBL558642; CTK8F0693; CHEBI:665844; HMS2043A20; UNII-56887611DJ; NCGC00250410-01; |
| In vitro | DMSO | 76 mg/mL (198.71 mM) |
|---|---|---|
| Water | <1 mg/mL | |
| Ethanol | <1 mg/mL | |
| In vivo |
| Description | GSK650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2, respectively. | ||||
|---|---|---|---|---|---|
| Targets |
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| In vitro |
GSK650394 inhibits SGK1-mediated epithelial transport with an IC50 of 0.6 μM in the SCC assay. In LNCaP cells, GSK650394 inhibits the androgen-mediated enhancement of Nedd4-2 phosphorylation and androgen-mediated cell growth. [2] GSK650394 counteracts the Cortisol-induced decrease in neurogenesis, changes in Hedgehog signaling, and GR nuclear translocation. [2] GSK 650394 inhibits replication of influenza virus by impairing the export of influenza vRNPs into the cytoplasm of A549 cells. [3] |