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NSC 14613, PluriSln 1

(CAS No:91396-88-2)

PluriSIn #1 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs.

CAS No:91396-88-2

Molecular Weight(MW):213.24

Purity:99.00%

Specification:500MG;1G;5G;10G;50G;100G

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QC Documents

COA	MSDS	HPLC	NMR

ChemicalInfomation

CAS No:	91396-88-2
Molecular formula(MF)	C₁₂H₁₁N₃O
Molecular Weight(MW):	213.24
Alias

Solubility

In vitro	DMSO	43 mg/mL (201.65 mM)
	Water	<1 mg/mL
	Ethanol	<1 mg/mL

Biological Activity

Description

PluriSIn #1 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs.

Targets

SCD1 ^[1]

In vitro

PluriSIns #1 has a robust, rapid, and selective cytotoxic effect toward hPSCs. Apoptosis is the central cell death mechanism activated by PluriSIn #1. PluriSIn #1 leads to ER stress in hPSCs. PluriSIn #1 (20 μM) induces ~30% decrease in protein synthesis in hPSCs. PluriSIn #1 exposure induces a ~65% decrease in stearoyl-coA desaturase (SCD1) activity in hPSCs. PluriSIn #1 (20 μM) prevents teratoma gormation from undifferentiated hPSCs PluriSIns also inhibits mPSCs and hinders mouse embryonic development. ^[1]